The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis
Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease associated with asthma and allergic rhinitis, and is dominated by Th2 cells. The co-stimulatory T-cell receptor OX40 and its ligand, OX40L, play a central role in the pathogenesis of AD, as their interactions ar...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2020-03-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3452
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| _version_ | 1819289140874706944 |
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| author | Julie Sophie Elsner Michael Carlsson Julie Kristine Stougaard Uffe Nygaard Matthias Buchner Regina Fölster-Holst Malene Hvid Christian Vestergaard Mette Deleuran Bent Deleuran |
| author_facet | Julie Sophie Elsner Michael Carlsson Julie Kristine Stougaard Uffe Nygaard Matthias Buchner Regina Fölster-Holst Malene Hvid Christian Vestergaard Mette Deleuran Bent Deleuran |
| author_sort | Julie Sophie Elsner |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease associated with asthma and allergic rhinitis, and is dominated by Th2 cells. The co-stimulatory T-cell receptor OX40 and its ligand, OX40L, play a central role in the pathogenesis of AD, as their interactions are crucial for the generation of TH2 memory cells. Using enzyme-linked immunoassay (ELISA) and flow cytometry on blood samples from patients with AD and healthy volunteers, this study shows that the serum level of soluble (s) OX40 is decreased in patients with AD, and the expression of OX40 by activated skin-homing CD4+ T cells is increased. This study further shows, using immunofluorescence on skin biopsies, that OX40+ and OX40L+ cells are co-located within the dermis, indicating local activity of OX40/OX40L. Serum levels of sOX40 were associated with atopic diseases and, together, these results support that the OX40 system is important for chronic inflammation in AD skin. |
| first_indexed | 2024-12-24T03:02:07Z |
| format | Article |
| id | doaj.art-95cf61c3196f4c55930c89e4038dde84 |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-12-24T03:02:07Z |
| publishDate | 2020-03-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-95cf61c3196f4c55930c89e4038dde842022-12-21T17:18:09ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572020-03-011006adv0009910.2340/00015555-34525712The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic DermatitisJulie Sophie Elsner0Michael CarlssonJulie Kristine StougaardUffe NygaardMatthias BuchnerRegina Fölster-HolstMalene HvidChristian VestergaardMette DeleuranBent Deleuran Atopic dermatitis (AD) is a chronic, or chronically relapsing, inflammatory skin disease associated with asthma and allergic rhinitis, and is dominated by Th2 cells. The co-stimulatory T-cell receptor OX40 and its ligand, OX40L, play a central role in the pathogenesis of AD, as their interactions are crucial for the generation of TH2 memory cells. Using enzyme-linked immunoassay (ELISA) and flow cytometry on blood samples from patients with AD and healthy volunteers, this study shows that the serum level of soluble (s) OX40 is decreased in patients with AD, and the expression of OX40 by activated skin-homing CD4+ T cells is increased. This study further shows, using immunofluorescence on skin biopsies, that OX40+ and OX40L+ cells are co-located within the dermis, indicating local activity of OX40/OX40L. Serum levels of sOX40 were associated with atopic diseases and, together, these results support that the OX40 system is important for chronic inflammation in AD skin. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3452 atopic dermatitis ox40 ox40l |
| spellingShingle | Julie Sophie Elsner Michael Carlsson Julie Kristine Stougaard Uffe Nygaard Matthias Buchner Regina Fölster-Holst Malene Hvid Christian Vestergaard Mette Deleuran Bent Deleuran The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis Acta Dermato-Venereologica atopic dermatitis ox40 ox40l |
| title | The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis |
| title_full | The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis |
| title_fullStr | The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis |
| title_full_unstemmed | The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis |
| title_short | The OX40 Axis is Associated with Both Systemic and Local Involvement in Atopic Dermatitis |
| title_sort | ox40 axis is associated with both systemic and local involvement in atopic dermatitis |
| topic | atopic dermatitis ox40 ox40l |
| url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3452
|
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