The Active Subunit of the Cytolethal Distending Toxin, CdtB, Derived From Both Haemophilus ducreyi and Campylobacter jejuni Exhibits Potent Phosphatidylinositol-3,4,5-Triphosphate Phosphatase Activity

The Active Subunit of the Cytolethal Distending Toxin, CdtB, Derived From Both Haemophilus ducreyi and Campylobacter jejuni Exhibits Potent Phosphatidylinositol-3,4,5-Triphosphate Phosphatase Activity

Human lymphocytes exposed to Aggregatibacter actinomycetemcomitans (Aa) cytolethal distending toxin (Cdt) undergo cell cycle arrest and apoptosis. In previous studies, we demonstrated that the active Cdt subunit, CdtB, is a potent phosphatidylinositol (PI) 3,4,5-triphosphate phosphatase. Moreover, A...

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Bibliographic Details
Main Authors: Grace Huang, Kathleen Boesze-Battaglia, Lisa P. Walker, Ali Zekavat, Zachary P. Schaefer, Steven R. Blanke, Bruce J. Shenker
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
cytolethal distending toxin
host-parasite interactions
lymphocytes
toxins
pathogenesis
cell cycle arrest
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.664221/full

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