Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies
I reflect on my experience working with David Y. Mason in the Leukaemia Research Laboratories in the Nuffield Department of Pathology at the University of Oxford in the early 1980s. This was soon after the first monoclonal antibodies had been produced, which led to an exciting and productive time in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/1/127 |
| _version_ | 1797499305071738880 |
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| author | Wendy N. Erber |
| author_facet | Wendy N. Erber |
| author_sort | Wendy N. Erber |
| collection | DOAJ |
| description | I reflect on my experience working with David Y. Mason in the Leukaemia Research Laboratories in the Nuffield Department of Pathology at the University of Oxford in the early 1980s. This was soon after the first monoclonal antibodies had been produced, which led to an exciting and productive time in biological discovery and pathology diagnostics. A specific focus in the laboratory was the development of immunoenzymatic staining methods that would enable monoclonal antibodies to be applied in diagnostic practice. This paper describes the work that led to the performance of immuno-alkaline phosphatase staining on blood and bone marrow smears, the success of which changed leukaemia diagnosis. |
| first_indexed | 2024-03-10T03:45:34Z |
| format | Article |
| id | doaj.art-95d368f44ad247988e7854ad4201a438 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T03:45:34Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-95d368f44ad247988e7854ad4201a4382023-11-23T11:20:36ZengMDPI AGCells2073-44092021-12-0111112710.3390/cells11010127Immunocytochemical Labelling of Haematological Samples Using Monoclonal AntibodiesWendy N. Erber0School of Biomedical Sciences, The University of Western Australia, Perth, WA 6009, AustraliaI reflect on my experience working with David Y. Mason in the Leukaemia Research Laboratories in the Nuffield Department of Pathology at the University of Oxford in the early 1980s. This was soon after the first monoclonal antibodies had been produced, which led to an exciting and productive time in biological discovery and pathology diagnostics. A specific focus in the laboratory was the development of immunoenzymatic staining methods that would enable monoclonal antibodies to be applied in diagnostic practice. This paper describes the work that led to the performance of immuno-alkaline phosphatase staining on blood and bone marrow smears, the success of which changed leukaemia diagnosis.https://www.mdpi.com/2073-4409/11/1/127monoclonal antibodiesdiagnosticsimmunoenzymatic |
| spellingShingle | Wendy N. Erber Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies Cells monoclonal antibodies diagnostics immunoenzymatic |
| title | Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies |
| title_full | Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies |
| title_fullStr | Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies |
| title_full_unstemmed | Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies |
| title_short | Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies |
| title_sort | immunocytochemical labelling of haematological samples using monoclonal antibodies |
| topic | monoclonal antibodies diagnostics immunoenzymatic |
| url | https://www.mdpi.com/2073-4409/11/1/127 |
| work_keys_str_mv | AT wendynerber immunocytochemicallabellingofhaematologicalsamplesusingmonoclonalantibodies |