The role of the ZEB1–neuroinflammation axis in CNS disorders
Abstract Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial–mesenchymal transition (EMT), a process whereby epithelial cells undergo a series of molecular changes and express certain characteristics of mesenchymal cells. ZEB1, in association with other EMT transcript...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12974-022-02636-2 |
| _version_ | 1797984083798654976 |
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| author | Elham Poonaki Ulf Dietrich Kahlert Sven G. Meuth Ali Gorji |
| author_facet | Elham Poonaki Ulf Dietrich Kahlert Sven G. Meuth Ali Gorji |
| author_sort | Elham Poonaki |
| collection | DOAJ |
| description | Abstract Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial–mesenchymal transition (EMT), a process whereby epithelial cells undergo a series of molecular changes and express certain characteristics of mesenchymal cells. ZEB1, in association with other EMT transcription factors, promotes neuroinflammation through changes in the production of inflammatory mediators, the morphology and function of immune cells, and multiple signaling pathways that mediate the inflammatory response. The ZEB1–neuroinflammation axis plays a pivotal role in the pathogenesis of different CNS disorders, such as brain tumors, multiple sclerosis, cerebrovascular diseases, and neuropathic pain, by promoting tumor cell proliferation and invasiveness, formation of the hostile inflammatory micromilieu surrounding neuronal tissues, dysfunction of microglia and astrocytes, impairment of angiogenesis, and dysfunction of the blood–brain barrier. Future studies are needed to elucidate whether the ZEB1–neuroinflammation axis could serve as a diagnostic, prognostic, and/or therapeutic target for CNS disorders. |
| first_indexed | 2024-04-11T06:56:57Z |
| format | Article |
| id | doaj.art-95d3fefeb4844cbfb0e9485efc8c4ca9 |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-04-11T06:56:57Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-95d3fefeb4844cbfb0e9485efc8c4ca92022-12-22T04:39:01ZengBMCJournal of Neuroinflammation1742-20942022-11-0119111610.1186/s12974-022-02636-2The role of the ZEB1–neuroinflammation axis in CNS disordersElham Poonaki0Ulf Dietrich Kahlert1Sven G. Meuth2Ali Gorji3Department of Neurology, Faculty of Medicine, Heinrich-Heine-UniversityMolecular and Experimental Surgery, Faculty of Medicine, University Clinic for General-, Visceral-, Vascular- and Transplantation Surgery, Otto-Von-Guericke-UniversityDepartment of Neurology, Faculty of Medicine, Heinrich-Heine-UniversityEpilepsy Research Center, Department of Neurosurgery, Westfälische Wilhelms-Universität MünsterAbstract Zinc finger E-box binding homeobox 1 (ZEB1) is a master modulator of the epithelial–mesenchymal transition (EMT), a process whereby epithelial cells undergo a series of molecular changes and express certain characteristics of mesenchymal cells. ZEB1, in association with other EMT transcription factors, promotes neuroinflammation through changes in the production of inflammatory mediators, the morphology and function of immune cells, and multiple signaling pathways that mediate the inflammatory response. The ZEB1–neuroinflammation axis plays a pivotal role in the pathogenesis of different CNS disorders, such as brain tumors, multiple sclerosis, cerebrovascular diseases, and neuropathic pain, by promoting tumor cell proliferation and invasiveness, formation of the hostile inflammatory micromilieu surrounding neuronal tissues, dysfunction of microglia and astrocytes, impairment of angiogenesis, and dysfunction of the blood–brain barrier. Future studies are needed to elucidate whether the ZEB1–neuroinflammation axis could serve as a diagnostic, prognostic, and/or therapeutic target for CNS disorders.https://doi.org/10.1186/s12974-022-02636-2GlioblastomaMicrogliaMetastasisNeural stem cellsMicroRNA |
| spellingShingle | Elham Poonaki Ulf Dietrich Kahlert Sven G. Meuth Ali Gorji The role of the ZEB1–neuroinflammation axis in CNS disorders Journal of Neuroinflammation Glioblastoma Microglia Metastasis Neural stem cells MicroRNA |
| title | The role of the ZEB1–neuroinflammation axis in CNS disorders |
| title_full | The role of the ZEB1–neuroinflammation axis in CNS disorders |
| title_fullStr | The role of the ZEB1–neuroinflammation axis in CNS disorders |
| title_full_unstemmed | The role of the ZEB1–neuroinflammation axis in CNS disorders |
| title_short | The role of the ZEB1–neuroinflammation axis in CNS disorders |
| title_sort | role of the zeb1 neuroinflammation axis in cns disorders |
| topic | Glioblastoma Microglia Metastasis Neural stem cells MicroRNA |
| url | https://doi.org/10.1186/s12974-022-02636-2 |
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