Amniotic fluid interleukin-6 and neutrophil gelatinase-associated lipocalin for predicting fetal inflammatory response syndrome based on histological chorioamnionitis and funisitis
Objective: We aimed to analyze the predictive efficacy of amniotic fluid interleukin-6 (IL-6) and neutrophil gelatinase-associated lipocalin (NGAL) for fetal inflammatory response syndrome (FIRS)-related infection. Materials and methods: We included singleton pregnancies classified into FIRS and non...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-07-01
|
Series: | Taiwanese Journal of Obstetrics & Gynecology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455923001237 |
_version_ | 1811153959803420672 |
---|---|
author | Daisuke Katsura Shunichiro Tsuji Kaori Hayashi Shinsuke Tokoro Takako Hoshiyama Nobuyuki Kita Takashi Murakami |
author_facet | Daisuke Katsura Shunichiro Tsuji Kaori Hayashi Shinsuke Tokoro Takako Hoshiyama Nobuyuki Kita Takashi Murakami |
author_sort | Daisuke Katsura |
collection | DOAJ |
description | Objective: We aimed to analyze the predictive efficacy of amniotic fluid interleukin-6 (IL-6) and neutrophil gelatinase-associated lipocalin (NGAL) for fetal inflammatory response syndrome (FIRS)-related infection. Materials and methods: We included singleton pregnancies classified into FIRS and non-FIRS groups. FIRS was defined as histologic chorioamnionitis and funisitis. Amniotic fluid samples were collected during vaginal delivery (VD) or cesarean section (CS). We compared amniotic fluid IL-6 and NGAL levels between the groups. Results: Forty-six pregnancies were analyzed and classified into 20 (43.5%) FIRS and 26 (56.5%) non-FIRS pregnancies. We observed significant differences in amniotic fluid IL-6 and NGAL. Amniotic fluid collection significantly influenced NGAL levels (p < 0.001). The area under the concentration–time curve (AUC), with optimal cutoff values, for amniotic fluid IL-6 and NGAL (VD and CS) levels was 0.948 (11,344 pg/mL), 0.800 (1180 ng/mL), and 0.946 (708 ng/mL), respectively. Conclusion: Amniotic fluid IL-6 and NGAL levels showed equivalent predictive ability for FIRS-related infection. |
first_indexed | 2024-03-13T01:19:38Z |
format | Article |
id | doaj.art-95d44f7cb7d34e65ace539ea8cb11abe |
institution | Directory Open Access Journal |
issn | 1028-4559 |
language | English |
last_indexed | 2024-03-13T01:19:38Z |
publishDate | 2023-07-01 |
publisher | Elsevier |
record_format | Article |
series | Taiwanese Journal of Obstetrics & Gynecology |
spelling | doaj.art-95d44f7cb7d34e65ace539ea8cb11abe2023-07-05T05:14:56ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592023-07-01624516520Amniotic fluid interleukin-6 and neutrophil gelatinase-associated lipocalin for predicting fetal inflammatory response syndrome based on histological chorioamnionitis and funisitisDaisuke Katsura0Shunichiro Tsuji1Kaori Hayashi2Shinsuke Tokoro3Takako Hoshiyama4Nobuyuki Kita5Takashi Murakami6Corresponding author.; Department of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanDepartment of Obstetrics and Gynecology, Shiga University of Medical Science Hospital, Otsu, JapanObjective: We aimed to analyze the predictive efficacy of amniotic fluid interleukin-6 (IL-6) and neutrophil gelatinase-associated lipocalin (NGAL) for fetal inflammatory response syndrome (FIRS)-related infection. Materials and methods: We included singleton pregnancies classified into FIRS and non-FIRS groups. FIRS was defined as histologic chorioamnionitis and funisitis. Amniotic fluid samples were collected during vaginal delivery (VD) or cesarean section (CS). We compared amniotic fluid IL-6 and NGAL levels between the groups. Results: Forty-six pregnancies were analyzed and classified into 20 (43.5%) FIRS and 26 (56.5%) non-FIRS pregnancies. We observed significant differences in amniotic fluid IL-6 and NGAL. Amniotic fluid collection significantly influenced NGAL levels (p < 0.001). The area under the concentration–time curve (AUC), with optimal cutoff values, for amniotic fluid IL-6 and NGAL (VD and CS) levels was 0.948 (11,344 pg/mL), 0.800 (1180 ng/mL), and 0.946 (708 ng/mL), respectively. Conclusion: Amniotic fluid IL-6 and NGAL levels showed equivalent predictive ability for FIRS-related infection.http://www.sciencedirect.com/science/article/pii/S1028455923001237Amniotic fluidFetal inflammatory response syndromeInterleukin-6Neutrophil gelatinase-associated lipocalin |
spellingShingle | Daisuke Katsura Shunichiro Tsuji Kaori Hayashi Shinsuke Tokoro Takako Hoshiyama Nobuyuki Kita Takashi Murakami Amniotic fluid interleukin-6 and neutrophil gelatinase-associated lipocalin for predicting fetal inflammatory response syndrome based on histological chorioamnionitis and funisitis Taiwanese Journal of Obstetrics & Gynecology Amniotic fluid Fetal inflammatory response syndrome Interleukin-6 Neutrophil gelatinase-associated lipocalin |
title | Amniotic fluid interleukin-6 and neutrophil gelatinase-associated lipocalin for predicting fetal inflammatory response syndrome based on histological chorioamnionitis and funisitis |
title_full | Amniotic fluid interleukin-6 and neutrophil gelatinase-associated lipocalin for predicting fetal inflammatory response syndrome based on histological chorioamnionitis and funisitis |
title_fullStr | Amniotic fluid interleukin-6 and neutrophil gelatinase-associated lipocalin for predicting fetal inflammatory response syndrome based on histological chorioamnionitis and funisitis |
title_full_unstemmed | Amniotic fluid interleukin-6 and neutrophil gelatinase-associated lipocalin for predicting fetal inflammatory response syndrome based on histological chorioamnionitis and funisitis |
title_short | Amniotic fluid interleukin-6 and neutrophil gelatinase-associated lipocalin for predicting fetal inflammatory response syndrome based on histological chorioamnionitis and funisitis |
title_sort | amniotic fluid interleukin 6 and neutrophil gelatinase associated lipocalin for predicting fetal inflammatory response syndrome based on histological chorioamnionitis and funisitis |
topic | Amniotic fluid Fetal inflammatory response syndrome Interleukin-6 Neutrophil gelatinase-associated lipocalin |
url | http://www.sciencedirect.com/science/article/pii/S1028455923001237 |
work_keys_str_mv | AT daisukekatsura amnioticfluidinterleukin6andneutrophilgelatinaseassociatedlipocalinforpredictingfetalinflammatoryresponsesyndromebasedonhistologicalchorioamnionitisandfunisitis AT shunichirotsuji amnioticfluidinterleukin6andneutrophilgelatinaseassociatedlipocalinforpredictingfetalinflammatoryresponsesyndromebasedonhistologicalchorioamnionitisandfunisitis AT kaorihayashi amnioticfluidinterleukin6andneutrophilgelatinaseassociatedlipocalinforpredictingfetalinflammatoryresponsesyndromebasedonhistologicalchorioamnionitisandfunisitis AT shinsuketokoro amnioticfluidinterleukin6andneutrophilgelatinaseassociatedlipocalinforpredictingfetalinflammatoryresponsesyndromebasedonhistologicalchorioamnionitisandfunisitis AT takakohoshiyama amnioticfluidinterleukin6andneutrophilgelatinaseassociatedlipocalinforpredictingfetalinflammatoryresponsesyndromebasedonhistologicalchorioamnionitisandfunisitis AT nobuyukikita amnioticfluidinterleukin6andneutrophilgelatinaseassociatedlipocalinforpredictingfetalinflammatoryresponsesyndromebasedonhistologicalchorioamnionitisandfunisitis AT takashimurakami amnioticfluidinterleukin6andneutrophilgelatinaseassociatedlipocalinforpredictingfetalinflammatoryresponsesyndromebasedonhistologicalchorioamnionitisandfunisitis |