Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer.
Lung cancer is a complex disease that often manifests at the point when treatment is not effective. Introduction of blood-based complementary diagnostics using molecular markers may enhance early detection of this disease and help reduce the burden of lung cancer. Here we evaluated the diagnostic po...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5074500?pdf=render |
| _version_ | 1818441574100500480 |
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| author | Ivan A Zaporozhchenko Evgeny S Morozkin Tatyana E Skvortsova Anastasia A Ponomaryova Elena Yu Rykova Nadezhda V Cherdyntseva Evgeny S Polovnikov Oksana A Pashkovskaya Evgeny A Pokushalov Valentin V Vlassov Pavel P Laktionov |
| author_facet | Ivan A Zaporozhchenko Evgeny S Morozkin Tatyana E Skvortsova Anastasia A Ponomaryova Elena Yu Rykova Nadezhda V Cherdyntseva Evgeny S Polovnikov Oksana A Pashkovskaya Evgeny A Pokushalov Valentin V Vlassov Pavel P Laktionov |
| author_sort | Ivan A Zaporozhchenko |
| collection | DOAJ |
| description | Lung cancer is a complex disease that often manifests at the point when treatment is not effective. Introduction of blood-based complementary diagnostics using molecular markers may enhance early detection of this disease and help reduce the burden of lung cancer. Here we evaluated the diagnostic potential of seven plasma miRNA biomarkers (miR-21, -19b, -126, -25, -205, -183, -125b) by quantitative reverse transcription PCR. Influence clinical and demographical characteristics, including age, tumor stage and cancer subtype on miRNA levels was investigated. Four miRNAs were significantly dysregulated (miR-19b, -21, -25, -183) in lung cancer patients. Combination of miR-19b and miR-183 provided detection of lung cancer with 94.7% sensitivity and 95.2% specificity (AUC = 0.990). Thus, miRNAs have shown the potential to discriminate histological subtypes of lung cancer and reliably distinguish lung cancer patients from healthy individuals. |
| first_indexed | 2024-12-14T18:30:25Z |
| format | Article |
| id | doaj.art-95d4ee917bac42e7a562173125169e30 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T18:30:25Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-95d4ee917bac42e7a562173125169e302022-12-21T22:51:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011110e016526110.1371/journal.pone.0165261Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer.Ivan A ZaporozhchenkoEvgeny S MorozkinTatyana E SkvortsovaAnastasia A PonomaryovaElena Yu RykovaNadezhda V CherdyntsevaEvgeny S PolovnikovOksana A PashkovskayaEvgeny A PokushalovValentin V VlassovPavel P LaktionovLung cancer is a complex disease that often manifests at the point when treatment is not effective. Introduction of blood-based complementary diagnostics using molecular markers may enhance early detection of this disease and help reduce the burden of lung cancer. Here we evaluated the diagnostic potential of seven plasma miRNA biomarkers (miR-21, -19b, -126, -25, -205, -183, -125b) by quantitative reverse transcription PCR. Influence clinical and demographical characteristics, including age, tumor stage and cancer subtype on miRNA levels was investigated. Four miRNAs were significantly dysregulated (miR-19b, -21, -25, -183) in lung cancer patients. Combination of miR-19b and miR-183 provided detection of lung cancer with 94.7% sensitivity and 95.2% specificity (AUC = 0.990). Thus, miRNAs have shown the potential to discriminate histological subtypes of lung cancer and reliably distinguish lung cancer patients from healthy individuals.http://europepmc.org/articles/PMC5074500?pdf=render |
| spellingShingle | Ivan A Zaporozhchenko Evgeny S Morozkin Tatyana E Skvortsova Anastasia A Ponomaryova Elena Yu Rykova Nadezhda V Cherdyntseva Evgeny S Polovnikov Oksana A Pashkovskaya Evgeny A Pokushalov Valentin V Vlassov Pavel P Laktionov Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer. PLoS ONE |
| title | Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer. |
| title_full | Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer. |
| title_fullStr | Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer. |
| title_full_unstemmed | Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer. |
| title_short | Plasma miR-19b and miR-183 as Potential Biomarkers of Lung Cancer. |
| title_sort | plasma mir 19b and mir 183 as potential biomarkers of lung cancer |
| url | http://europepmc.org/articles/PMC5074500?pdf=render |
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