Synthesis, infrared spectra, thermogravimetric analysis, antibacterial and antitumor activities of Ni(Ⅱ)ofloxacin complex(氧氟沙星镍配合物的合成、红外光谱、热分析与抗肿瘤活性)
合成了以氧氟沙星为配体的镍（Ⅱ )配合物Ni(ofo)2 • 4H2O，通过红外光谱和热分析等方法对配合物的结构进行了表征，推测了配合物的可能结构，并利用液体稀释法测定了药物配体和配合物对两种革兰氏阳性菌和两种革兰氏阴性菌的体外抑制活性.结果表明配合物与药物配体的抗菌活性和抗菌谱相同.采用MTT比色法测定了配体及配合物对HL-60（人急性早幼粒白血病）细胞的抑制作用，采用SRB蛋白染色法测定了配体及配合物对BEL-7402（人肝细胞性肝癌）细胞的抑制作用.结果表明Ni(ofo)2 • 4H2O对BEL-7402细胞没有抑制作用，对HL-60细胞在较高浓度时有一定的抑制作用....
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| Format: | Article |
| Language: | zho |
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Zhejiang University Press
2008-09-01
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| Series: | Zhejiang Daxue xuebao. Lixue ban |
| Subjects: | |
| Online Access: | https://doi.org/10.3785/j.issn.1008-9497.2008.05.018 |
| _version_ | 1797236161160151040 |
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| author | CHENWei(陈威) LEIQun-fang(雷群芳) WANGGuo-ping(王国平) |
| author_facet | CHENWei(陈威) LEIQun-fang(雷群芳) WANGGuo-ping(王国平) |
| author_sort | CHENWei(陈威) |
| collection | DOAJ |
| description | 合成了以氧氟沙星为配体的镍（Ⅱ )配合物Ni(ofo)2 • 4H2O，通过红外光谱和热分析等方法对配合物的结构进行了表征，推测了配合物的可能结构，并利用液体稀释法测定了药物配体和配合物对两种革兰氏阳性菌和两种革兰氏阴性菌的体外抑制活性.结果表明配合物与药物配体的抗菌活性和抗菌谱相同.采用MTT比色法测定了配体及配合物对HL-60（人急性早幼粒白血病）细胞的抑制作用，采用SRB蛋白染色法测定了配体及配合物对BEL-7402（人肝细胞性肝癌）细胞的抑制作用.结果表明Ni(ofo)2 • 4H2O对BEL-7402细胞没有抑制作用，对HL-60细胞在较高浓度时有一定的抑制作用. |
| first_indexed | 2024-04-24T16:59:27Z |
| format | Article |
| id | doaj.art-95d776725d0d496a804f8702a6d6ffa5 |
| institution | Directory Open Access Journal |
| issn | 1008-9497 |
| language | zho |
| last_indexed | 2024-04-24T16:59:27Z |
| publishDate | 2008-09-01 |
| publisher | Zhejiang University Press |
| record_format | Article |
| series | Zhejiang Daxue xuebao. Lixue ban |
| spelling | doaj.art-95d776725d0d496a804f8702a6d6ffa52024-03-29T01:58:26ZzhoZhejiang University PressZhejiang Daxue xuebao. Lixue ban1008-94972008-09-0135555355610.3785/j.issn.1008-9497.2008.05.018Synthesis, infrared spectra, thermogravimetric analysis, antibacterial and antitumor activities of Ni(Ⅱ)ofloxacin complex(氧氟沙星镍配合物的合成、红外光谱、热分析与抗肿瘤活性)CHENWei(陈威)0LEIQun-fang(雷群芳)1WANGGuo-ping(王国平)2Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)Department of Chemistry, Zhejiang University, Hangzhou 310027, China(浙江大学化学系，浙江 杭州 310027)合成了以氧氟沙星为配体的镍（Ⅱ )配合物Ni(ofo)2 • 4H2O，通过红外光谱和热分析等方法对配合物的结构进行了表征，推测了配合物的可能结构，并利用液体稀释法测定了药物配体和配合物对两种革兰氏阳性菌和两种革兰氏阴性菌的体外抑制活性.结果表明配合物与药物配体的抗菌活性和抗菌谱相同.采用MTT比色法测定了配体及配合物对HL-60（人急性早幼粒白血病）细胞的抑制作用，采用SRB蛋白染色法测定了配体及配合物对BEL-7402（人肝细胞性肝癌）细胞的抑制作用.结果表明Ni(ofo)2 • 4H2O对BEL-7402细胞没有抑制作用，对HL-60细胞在较高浓度时有一定的抑制作用.https://doi.org/10.3785/j.issn.1008-9497.2008.05.018配合物氧氟沙星红外光谱热分析抗菌活性抗肿瘤活性 |
| spellingShingle | CHENWei(陈威) LEIQun-fang(雷群芳) WANGGuo-ping(王国平) Synthesis, infrared spectra, thermogravimetric analysis, antibacterial and antitumor activities of Ni(Ⅱ)ofloxacin complex(氧氟沙星镍配合物的合成、红外光谱、热分析与抗肿瘤活性) Zhejiang Daxue xuebao. Lixue ban 配合物 氧氟沙星 红外光谱 热分析 抗菌活性 抗肿瘤活性 |
| title | Synthesis, infrared spectra, thermogravimetric analysis, antibacterial and antitumor activities of Ni(Ⅱ)ofloxacin complex(氧氟沙星镍配合物的合成、红外光谱、热分析与抗肿瘤活性) |
| title_full | Synthesis, infrared spectra, thermogravimetric analysis, antibacterial and antitumor activities of Ni(Ⅱ)ofloxacin complex(氧氟沙星镍配合物的合成、红外光谱、热分析与抗肿瘤活性) |
| title_fullStr | Synthesis, infrared spectra, thermogravimetric analysis, antibacterial and antitumor activities of Ni(Ⅱ)ofloxacin complex(氧氟沙星镍配合物的合成、红外光谱、热分析与抗肿瘤活性) |
| title_full_unstemmed | Synthesis, infrared spectra, thermogravimetric analysis, antibacterial and antitumor activities of Ni(Ⅱ)ofloxacin complex(氧氟沙星镍配合物的合成、红外光谱、热分析与抗肿瘤活性) |
| title_short | Synthesis, infrared spectra, thermogravimetric analysis, antibacterial and antitumor activities of Ni(Ⅱ)ofloxacin complex(氧氟沙星镍配合物的合成、红外光谱、热分析与抗肿瘤活性) |
| title_sort | synthesis infrared spectra thermogravimetric analysis antibacterial and antitumor activities of ni ii ofloxacin complex 氧氟沙星镍配合物的合成 红外光谱 热分析与抗肿瘤活性 |
| topic | 配合物 氧氟沙星 红外光谱 热分析 抗菌活性 抗肿瘤活性 |
| url | https://doi.org/10.3785/j.issn.1008-9497.2008.05.018 |
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