Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A Perspective
Regular exercise plays an essential role in maintaining healthy neurocognitive function and central nervous system (CNS) immuno-metabolism in the aging CNS. Physical activity decreases the risk of developing Alzheimer's Disease (AD), is associated with better AD prognosis, and positively affect...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.649452/full |
| _version_ | 1818740408051564544 |
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| author | Rajesh Gupta Rizwan Khan Constanza J. Cortes Constanza J. Cortes Constanza J. Cortes Constanza J. Cortes |
| author_facet | Rajesh Gupta Rizwan Khan Constanza J. Cortes Constanza J. Cortes Constanza J. Cortes Constanza J. Cortes |
| author_sort | Rajesh Gupta |
| collection | DOAJ |
| description | Regular exercise plays an essential role in maintaining healthy neurocognitive function and central nervous system (CNS) immuno-metabolism in the aging CNS. Physical activity decreases the risk of developing Alzheimer's Disease (AD), is associated with better AD prognosis, and positively affects cognitive function in AD patients. Skeletal muscle is an important secretory organ, communicating proteotoxic and metabolic stress to distant tissues, including the CNS, through the secretion of bioactive molecules collectively known as myokines. Skeletal muscle undergoes significant physical and metabolic remodeling during exercise, including alterations in myokine expression profiles. This suggests that changes in myokine and myometabolite secretion may underlie the well-documented benefits of exercise in AD. However, to date, very few studies have focused on specific alterations in skeletal muscle-originating secreted factors and their potential neuroprotective effects in AD. In this review, we discuss exercise therapy for AD prevention and intervention, and propose the use of circulating myokines as novel therapeutic tools for modifying AD progression. |
| first_indexed | 2024-12-18T01:40:15Z |
| format | Article |
| id | doaj.art-95d93ca2358641e59b202f71291b8233 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-18T01:40:15Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-95d93ca2358641e59b202f71291b82332022-12-21T21:25:20ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-06-011210.3389/fneur.2021.649452649452Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A PerspectiveRajesh Gupta0Rizwan Khan1Constanza J. Cortes2Constanza J. Cortes3Constanza J. Cortes4Constanza J. Cortes5Department of Cell, Developmental and Integrative Biology (CDIB), School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Cell, Developmental and Integrative Biology (CDIB), School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesDepartment of Cell, Developmental and Integrative Biology (CDIB), School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesCenter for Neurodegeneration and Experimental Therapeutics (CNET), University of Alabama at Birmingham, Birmingham, AL, United StatesCenter for Exercise Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United StatesUAB Nathan Shock Center for the Excellence in the Study of Aging, University of Alabama at Birmingman, Birmingham, AL, United StatesRegular exercise plays an essential role in maintaining healthy neurocognitive function and central nervous system (CNS) immuno-metabolism in the aging CNS. Physical activity decreases the risk of developing Alzheimer's Disease (AD), is associated with better AD prognosis, and positively affects cognitive function in AD patients. Skeletal muscle is an important secretory organ, communicating proteotoxic and metabolic stress to distant tissues, including the CNS, through the secretion of bioactive molecules collectively known as myokines. Skeletal muscle undergoes significant physical and metabolic remodeling during exercise, including alterations in myokine expression profiles. This suggests that changes in myokine and myometabolite secretion may underlie the well-documented benefits of exercise in AD. However, to date, very few studies have focused on specific alterations in skeletal muscle-originating secreted factors and their potential neuroprotective effects in AD. In this review, we discuss exercise therapy for AD prevention and intervention, and propose the use of circulating myokines as novel therapeutic tools for modifying AD progression.https://www.frontiersin.org/articles/10.3389/fneur.2021.649452/fullexerciseagingmyokinesexerkinesneuroprotection |
| spellingShingle | Rajesh Gupta Rizwan Khan Constanza J. Cortes Constanza J. Cortes Constanza J. Cortes Constanza J. Cortes Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A Perspective Frontiers in Neurology exercise aging myokines exerkines neuroprotection |
| title | Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A Perspective |
| title_full | Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A Perspective |
| title_fullStr | Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A Perspective |
| title_full_unstemmed | Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A Perspective |
| title_short | Forgot to Exercise? Exercise Derived Circulating Myokines in Alzheimer's Disease: A Perspective |
| title_sort | forgot to exercise exercise derived circulating myokines in alzheimer s disease a perspective |
| topic | exercise aging myokines exerkines neuroprotection |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.649452/full |
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