Intracellular zinc is a critical intermediate in the excitotoxic cascade
Excessive and sustained exposure to glutamate leads to injurious elevations of cytosolic calcium ([Ca2+]i), generation of reactive oxygen and nitrogen species (ROS, RNS), mitochondrial failure, mobilization of intracellular zinc ([Zn2+]i), and, ultimately, neuronal death. The relative contribution a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-09-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996115001576 |