Advances in using PARP inhibitors to treat cancer

Advances in using PARP inhibitors to treat cancer

<p>Abstract</p> <p>The poly (ADP-ribose) polymerase (PARP) family of enzymes plays a critical role in the maintenance of DNA integrity as part of the base excision pathway of DNA repair. PARP1 is overexpressed in a variety of cancers, and its expression has been associated with ove...

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Bibliographic Details
Main Authors: Kummar Shivaani, Chen Alice, Parchment Ralph E, Kinders Robert J, Ji Jay, Tomaszewski Joseph E, Doroshow James H
Format: Article
Language:English
Published: BMC 2012-03-01
Series:BMC Medicine
Subjects:
synthetic lethality
DNA repair
PARP clinical trials
Online Access:http://www.biomedcentral.com/1741-7015/10/25

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