Weak complexation of 5-fluorouracil with β-cyclodextrin, carbonate, and dianhydride crosslinked β-cyclodextrin: in vitro and in silico studies

Weak complexation of 5-fluorouracil with β-cyclodextrin, carbonate, and dianhydride crosslinked β-cyclodextrin: in vitro and in silico studies

Background and purpose: Several pharmaceutical formulations were investigated to improve the solubility of 5-fluorouracil to enhance bioavailability and therapeutic efficacy. This study aimed to examine the potential use of cyclodextrin-based nanosponges for the incorporation of 5-fluorouracil and t...

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Bibliographic Details
Main Authors:	Hadeia Mashaqbeh, Rana Obaidat, Nizar A Al-Shar’i, Tamam El-Elimat, Soraya Alnabulsi
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2022-01-01
Series:	Research in Pharmaceutical Sciences
Subjects:	β-cyclodextrin-based nanosponges; complexation; crosslinking agent; 5-fluorouracil.
Online Access:	http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2022;volume=17;issue=4;spage=334;epage=349;aulast=Mashaqbeh

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