Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures
Genetic instability can result from increases in DNA damage and/or alterations in DNA repair proteins and can contribute to disease development. Both exogenous and endogenous sources of DNA damage and/or alterations in DNA structure (e.g., non-B DNA) can impact genome stability. Multiple repair mech...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | DNA |
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| Online Access: | https://www.mdpi.com/2673-8856/2/4/17 |
| _version_ | 1797460475125956608 |
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| author | Tonia T. Li Karen M. Vasquez |
| author_facet | Tonia T. Li Karen M. Vasquez |
| author_sort | Tonia T. Li |
| collection | DOAJ |
| description | Genetic instability can result from increases in DNA damage and/or alterations in DNA repair proteins and can contribute to disease development. Both exogenous and endogenous sources of DNA damage and/or alterations in DNA structure (e.g., non-B DNA) can impact genome stability. Multiple repair mechanisms exist to counteract DNA damage. One key DNA repair protein complex is ERCC1-XPF, a structure-specific endonuclease that participates in a variety of DNA repair processes. ERCC1-XPF is involved in nucleotide excision repair (NER), repair of DNA interstrand crosslinks (ICLs), and DNA double-strand break (DSB) repair via homologous recombination. In addition, ERCC1-XPF contributes to the processing of various alternative (i.e., non-B) DNA structures. This review will focus on the processing of alternative DNA structures by ERCC1-XPF. |
| first_indexed | 2024-03-09T17:05:36Z |
| format | Article |
| id | doaj.art-95dc28d977244d9d9018d62ee176f342 |
| institution | Directory Open Access Journal |
| issn | 2673-8856 |
| language | English |
| last_indexed | 2024-03-09T17:05:36Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | DNA |
| spelling | doaj.art-95dc28d977244d9d9018d62ee176f3422023-11-24T14:24:26ZengMDPI AGDNA2673-88562022-10-012423124710.3390/dna2040017Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA StructuresTonia T. Li0Karen M. Vasquez1Division of Pharmacology and Toxicology, Dell Pediatric Research Institute, College of Pharmacy, The University of Texas at Austin, 1400 Barbara Jordan Boulevard, Austin, TX 78723, USADivision of Pharmacology and Toxicology, Dell Pediatric Research Institute, College of Pharmacy, The University of Texas at Austin, 1400 Barbara Jordan Boulevard, Austin, TX 78723, USAGenetic instability can result from increases in DNA damage and/or alterations in DNA repair proteins and can contribute to disease development. Both exogenous and endogenous sources of DNA damage and/or alterations in DNA structure (e.g., non-B DNA) can impact genome stability. Multiple repair mechanisms exist to counteract DNA damage. One key DNA repair protein complex is ERCC1-XPF, a structure-specific endonuclease that participates in a variety of DNA repair processes. ERCC1-XPF is involved in nucleotide excision repair (NER), repair of DNA interstrand crosslinks (ICLs), and DNA double-strand break (DSB) repair via homologous recombination. In addition, ERCC1-XPF contributes to the processing of various alternative (i.e., non-B) DNA structures. This review will focus on the processing of alternative DNA structures by ERCC1-XPF.https://www.mdpi.com/2673-8856/2/4/17non-B DNA structureDNA repairERCC1-XPFgenetic instability |
| spellingShingle | Tonia T. Li Karen M. Vasquez Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures DNA non-B DNA structure DNA repair ERCC1-XPF genetic instability |
| title | Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures |
| title_full | Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures |
| title_fullStr | Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures |
| title_full_unstemmed | Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures |
| title_short | Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures |
| title_sort | multi faceted roles of ercc1 xpf nuclease in processing non b dna structures |
| topic | non-B DNA structure DNA repair ERCC1-XPF genetic instability |
| url | https://www.mdpi.com/2673-8856/2/4/17 |
| work_keys_str_mv | AT toniatli multifacetedrolesofercc1xpfnucleaseinprocessingnonbdnastructures AT karenmvasquez multifacetedrolesofercc1xpfnucleaseinprocessingnonbdnastructures |