Effect of narrow band ultraviolet B phototherapy on T helper 17 cell specific cytokines (interleukins-17, 22 and 23) in psoriasis vulgaris
Background: Psoriasis is mediated by a T helper 17 (Th17) cell inflammatory process. This study describes the changes in serum levels of IL-17, 22 and 23 in patients of psoriasis vulgaris treated with narrow band ultraviolet B (NBUVB). Methods: The serum levels of IL-17, 22 and 23 were compared with...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2016.1177162 |
| _version_ | 1797684015193391104 |
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| author | S. Bajaj R. K. Gautam A. Khurana P. Arora N. Sharma |
| author_facet | S. Bajaj R. K. Gautam A. Khurana P. Arora N. Sharma |
| author_sort | S. Bajaj |
| collection | DOAJ |
| description | Background: Psoriasis is mediated by a T helper 17 (Th17) cell inflammatory process. This study describes the changes in serum levels of IL-17, 22 and 23 in patients of psoriasis vulgaris treated with narrow band ultraviolet B (NBUVB). Methods: The serum levels of IL-17, 22 and 23 were compared with a control group (n = 30) before and after NBUVB. In addition, post-NBUVB levels were compared with healthy controls. Psoriasis Area Severity Score (PASI) and Body Surface Area scoring were used to evaluate severity of disease. Results: When compared with the non-psoriasis control group, IL-17, 22 and 23 were higher in psoriasis patients (p < 0.05, p < 0.001, p < 0.001, respectively). The serum levels of all three interleukins strongly correlated with severity of disease. Although IL-17, 22 and 23 decreased after NBUVB, decline in IL-17 was not significant after phototherapy as compared to controls (p = 0.634). IL-22 and 23 continued to remain elevated post-phototherapy when compared with control group (p < 0.05, p < 0.0001, respectively). Conclusions: The serum levels of IL-17, 22 and 23 decrease after phototherapy in psoriasis. Post-phototherapy only the IL-17 levels decrease to that of non-psoriasis controls. Our study supports the role of T helper 17 cell specific cytokines in psoriasis and a possible mechanism of action of NBUVB via inhibition of these cytokines. |
| first_indexed | 2024-03-12T00:23:14Z |
| format | Article |
| id | doaj.art-95dcdd405d894e7d80c4ff9bcd0292f6 |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:23:14Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-95dcdd405d894e7d80c4ff9bcd0292f62023-09-15T10:48:02ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532017-01-01281141710.1080/09546634.2016.11771621177162Effect of narrow band ultraviolet B phototherapy on T helper 17 cell specific cytokines (interleukins-17, 22 and 23) in psoriasis vulgarisS. Bajaj0R. K. Gautam1A. Khurana2P. Arora3N. Sharma4PGIMER Dr RML HospitalPGIMER Dr RML HospitalPGIMER Dr RML HospitalPGIMER Dr RML HospitalPGIMER Dr RML HospitalBackground: Psoriasis is mediated by a T helper 17 (Th17) cell inflammatory process. This study describes the changes in serum levels of IL-17, 22 and 23 in patients of psoriasis vulgaris treated with narrow band ultraviolet B (NBUVB). Methods: The serum levels of IL-17, 22 and 23 were compared with a control group (n = 30) before and after NBUVB. In addition, post-NBUVB levels were compared with healthy controls. Psoriasis Area Severity Score (PASI) and Body Surface Area scoring were used to evaluate severity of disease. Results: When compared with the non-psoriasis control group, IL-17, 22 and 23 were higher in psoriasis patients (p < 0.05, p < 0.001, p < 0.001, respectively). The serum levels of all three interleukins strongly correlated with severity of disease. Although IL-17, 22 and 23 decreased after NBUVB, decline in IL-17 was not significant after phototherapy as compared to controls (p = 0.634). IL-22 and 23 continued to remain elevated post-phototherapy when compared with control group (p < 0.05, p < 0.0001, respectively). Conclusions: The serum levels of IL-17, 22 and 23 decrease after phototherapy in psoriasis. Post-phototherapy only the IL-17 levels decrease to that of non-psoriasis controls. Our study supports the role of T helper 17 cell specific cytokines in psoriasis and a possible mechanism of action of NBUVB via inhibition of these cytokines.http://dx.doi.org/10.1080/09546634.2016.1177162phototherapyimmunology of psoriasispathogenesis of psoriasisil-17/t helper 17 cell axis |
| spellingShingle | S. Bajaj R. K. Gautam A. Khurana P. Arora N. Sharma Effect of narrow band ultraviolet B phototherapy on T helper 17 cell specific cytokines (interleukins-17, 22 and 23) in psoriasis vulgaris Journal of Dermatological Treatment phototherapy immunology of psoriasis pathogenesis of psoriasis il-17/t helper 17 cell axis |
| title | Effect of narrow band ultraviolet B phototherapy on T helper 17 cell specific cytokines (interleukins-17, 22 and 23) in psoriasis vulgaris |
| title_full | Effect of narrow band ultraviolet B phototherapy on T helper 17 cell specific cytokines (interleukins-17, 22 and 23) in psoriasis vulgaris |
| title_fullStr | Effect of narrow band ultraviolet B phototherapy on T helper 17 cell specific cytokines (interleukins-17, 22 and 23) in psoriasis vulgaris |
| title_full_unstemmed | Effect of narrow band ultraviolet B phototherapy on T helper 17 cell specific cytokines (interleukins-17, 22 and 23) in psoriasis vulgaris |
| title_short | Effect of narrow band ultraviolet B phototherapy on T helper 17 cell specific cytokines (interleukins-17, 22 and 23) in psoriasis vulgaris |
| title_sort | effect of narrow band ultraviolet b phototherapy on t helper 17 cell specific cytokines interleukins 17 22 and 23 in psoriasis vulgaris |
| topic | phototherapy immunology of psoriasis pathogenesis of psoriasis il-17/t helper 17 cell axis |
| url | http://dx.doi.org/10.1080/09546634.2016.1177162 |
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