The Function of microRNAs in Pulmonary Embolism: Review and Research Outlook
Pulmonary embolism (PE) is a common pathologic condition that frequently occurs in patients with deep venous thrombosis. Severe PE may critically suppress cardiopulmonary function, thereby threatening the life of patients. Chronic pulmonary hypertension caused by PE may lead to deterioration of resp...
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| Format: | Article |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.743945/full |
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| author | Mingyao Luo Mingyuan Du Mingyuan Du Chang Shu Chang Shu Chang Shu Sheng Liu Jiehua Li Jiehua Li Lei Zhang Lei Zhang Xin Li Xin Li |
| author_facet | Mingyao Luo Mingyuan Du Mingyuan Du Chang Shu Chang Shu Chang Shu Sheng Liu Jiehua Li Jiehua Li Lei Zhang Lei Zhang Xin Li Xin Li |
| author_sort | Mingyao Luo |
| collection | DOAJ |
| description | Pulmonary embolism (PE) is a common pathologic condition that frequently occurs in patients with deep venous thrombosis. Severe PE may critically suppress cardiopulmonary function, thereby threatening the life of patients. Chronic pulmonary hypertension caused by PE may lead to deterioration of respiratory dysfunction, resulting in complete disability. MicroRNAs (miRNAs) are a group of abundantly expressed non-coding RNAs that exert multiple functions in regulating the transcriptome via post-transcriptional targeting of mRNAs. Specifically, miRNAs bind to target mRNAs in a matching mechanism between the miRNA seed sequence and mRNA 3ʹ UTR, thus modulating the transcript stability or subsequent translation activity by RNA-induced silencing complex. Current studies have reported the function of miRNAs as biomarkers of PE, revealing their mechanism, function, and targetome in venous thrombophilia. This review summarizes the literature on miRNA functions and downstream mechanisms in PE. We conclude that various related miRNAs play important roles in PE and have great potential as treatment targets. For clinical application, we propose that miRNA biomarkers combined with traditional biomarkers or miRNA signatures generated from microchips may serve as a great predictive tool for PE occurrence and prognosis. Further, therapies targeting miRNAs or their upstream/downstream molecules need to be developed more quickly to keep up with the progress of routine treatments, such as anticoagulation, thrombolysis, or surgery. |
| first_indexed | 2024-04-11T15:10:42Z |
| format | Article |
| id | doaj.art-95dd1af2a01f4a578d18c45268e227e5 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T15:10:42Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-95dd1af2a01f4a578d18c45268e227e52022-12-22T04:16:39ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-10-011210.3389/fphar.2021.743945743945The Function of microRNAs in Pulmonary Embolism: Review and Research OutlookMingyao Luo0Mingyuan Du1Mingyuan Du2Chang Shu3Chang Shu4Chang Shu5Sheng Liu6Jiehua Li7Jiehua Li8Lei Zhang9Lei Zhang10Xin Li11Xin Li12State Key Laboratory of Cardiovascular Diseases, Center of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, ChinaThe Institute of Vascular Diseases, Central South University, Changsha, ChinaState Key Laboratory of Cardiovascular Diseases, Center of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, ChinaThe Institute of Vascular Diseases, Central South University, Changsha, ChinaState Key Laboratory of Cardiovascular Diseases, Center of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, ChinaThe Institute of Vascular Diseases, Central South University, Changsha, ChinaDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, ChinaThe Institute of Vascular Diseases, Central South University, Changsha, ChinaDepartment of Vascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, ChinaThe Institute of Vascular Diseases, Central South University, Changsha, ChinaPulmonary embolism (PE) is a common pathologic condition that frequently occurs in patients with deep venous thrombosis. Severe PE may critically suppress cardiopulmonary function, thereby threatening the life of patients. Chronic pulmonary hypertension caused by PE may lead to deterioration of respiratory dysfunction, resulting in complete disability. MicroRNAs (miRNAs) are a group of abundantly expressed non-coding RNAs that exert multiple functions in regulating the transcriptome via post-transcriptional targeting of mRNAs. Specifically, miRNAs bind to target mRNAs in a matching mechanism between the miRNA seed sequence and mRNA 3ʹ UTR, thus modulating the transcript stability or subsequent translation activity by RNA-induced silencing complex. Current studies have reported the function of miRNAs as biomarkers of PE, revealing their mechanism, function, and targetome in venous thrombophilia. This review summarizes the literature on miRNA functions and downstream mechanisms in PE. We conclude that various related miRNAs play important roles in PE and have great potential as treatment targets. For clinical application, we propose that miRNA biomarkers combined with traditional biomarkers or miRNA signatures generated from microchips may serve as a great predictive tool for PE occurrence and prognosis. Further, therapies targeting miRNAs or their upstream/downstream molecules need to be developed more quickly to keep up with the progress of routine treatments, such as anticoagulation, thrombolysis, or surgery.https://www.frontiersin.org/articles/10.3389/fphar.2021.743945/fullmiRNAbiomarkertreatment targetpulmonary embolismdeep venous thrombosismolecular regulation |
| spellingShingle | Mingyao Luo Mingyuan Du Mingyuan Du Chang Shu Chang Shu Chang Shu Sheng Liu Jiehua Li Jiehua Li Lei Zhang Lei Zhang Xin Li Xin Li The Function of microRNAs in Pulmonary Embolism: Review and Research Outlook Frontiers in Pharmacology miRNA biomarker treatment target pulmonary embolism deep venous thrombosis molecular regulation |
| title | The Function of microRNAs in Pulmonary Embolism: Review and Research Outlook |
| title_full | The Function of microRNAs in Pulmonary Embolism: Review and Research Outlook |
| title_fullStr | The Function of microRNAs in Pulmonary Embolism: Review and Research Outlook |
| title_full_unstemmed | The Function of microRNAs in Pulmonary Embolism: Review and Research Outlook |
| title_short | The Function of microRNAs in Pulmonary Embolism: Review and Research Outlook |
| title_sort | function of micrornas in pulmonary embolism review and research outlook |
| topic | miRNA biomarker treatment target pulmonary embolism deep venous thrombosis molecular regulation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.743945/full |
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