Murine malaria is associated with significant hearing impairment
<p>Abstract</p> <p>Background</p> <p><it>Plasmodium falciparum </it>malaria has been suspected to cause hearing loss. Developmental, cognitive and language disorders have been observed in children, surviving cerebral malaria. This prospective study aims to e...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-06-01
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| Series: | Malaria Journal |
| Online Access: | http://www.malariajournal.com/content/9/1/159 |
| _version_ | 1818035987567083520 |
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| author | Stephan Kurt Reindl Markus Glueckert Rudolf Fischer Marlene Dietmann Anelia Lackner Peter Kositz Christian H Schmutzhard Joachim Riechelmann Herbert Schrott-Fischer Annelies Schmutzhard Erich |
| author_facet | Stephan Kurt Reindl Markus Glueckert Rudolf Fischer Marlene Dietmann Anelia Lackner Peter Kositz Christian H Schmutzhard Joachim Riechelmann Herbert Schrott-Fischer Annelies Schmutzhard Erich |
| author_sort | Stephan Kurt |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p><it>Plasmodium falciparum </it>malaria has been suspected to cause hearing loss. Developmental, cognitive and language disorders have been observed in children, surviving cerebral malaria. This prospective study aims to evaluate whether malaria influences hearing in mice.</p> <p>Methods</p> <p>Twenty mice were included in a standardized murine cerebral malaria model. Auditory evoked brainstem responses were assessed before infection and at the peak of the illness.</p> <p>Results</p> <p>A significant hearing impairment could be demonstrated in mice with malaria, especially the cerebral form. The control group did not show any alterations. No therapy was used.</p> <p>Conclusion</p> <p>This suggests that malaria itself leads to a hearing impairment in mice.</p> |
| first_indexed | 2024-12-10T07:03:47Z |
| format | Article |
| id | doaj.art-95deb71b12ca42c09b81b9f376d7e600 |
| institution | Directory Open Access Journal |
| issn | 1475-2875 |
| language | English |
| last_indexed | 2024-12-10T07:03:47Z |
| publishDate | 2010-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj.art-95deb71b12ca42c09b81b9f376d7e6002022-12-22T01:58:15ZengBMCMalaria Journal1475-28752010-06-019115910.1186/1475-2875-9-159Murine malaria is associated with significant hearing impairmentStephan KurtReindl MarkusGlueckert RudolfFischer MarleneDietmann AneliaLackner PeterKositz Christian HSchmutzhard JoachimRiechelmann HerbertSchrott-Fischer AnneliesSchmutzhard Erich<p>Abstract</p> <p>Background</p> <p><it>Plasmodium falciparum </it>malaria has been suspected to cause hearing loss. Developmental, cognitive and language disorders have been observed in children, surviving cerebral malaria. This prospective study aims to evaluate whether malaria influences hearing in mice.</p> <p>Methods</p> <p>Twenty mice were included in a standardized murine cerebral malaria model. Auditory evoked brainstem responses were assessed before infection and at the peak of the illness.</p> <p>Results</p> <p>A significant hearing impairment could be demonstrated in mice with malaria, especially the cerebral form. The control group did not show any alterations. No therapy was used.</p> <p>Conclusion</p> <p>This suggests that malaria itself leads to a hearing impairment in mice.</p>http://www.malariajournal.com/content/9/1/159 |
| spellingShingle | Stephan Kurt Reindl Markus Glueckert Rudolf Fischer Marlene Dietmann Anelia Lackner Peter Kositz Christian H Schmutzhard Joachim Riechelmann Herbert Schrott-Fischer Annelies Schmutzhard Erich Murine malaria is associated with significant hearing impairment Malaria Journal |
| title | Murine malaria is associated with significant hearing impairment |
| title_full | Murine malaria is associated with significant hearing impairment |
| title_fullStr | Murine malaria is associated with significant hearing impairment |
| title_full_unstemmed | Murine malaria is associated with significant hearing impairment |
| title_short | Murine malaria is associated with significant hearing impairment |
| title_sort | murine malaria is associated with significant hearing impairment |
| url | http://www.malariajournal.com/content/9/1/159 |
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