Cold Exposure Regulates Hepatic Glycogen and Lipid Metabolism in Newborn Goats
Cold exposure influences liver metabolism, thereby affecting energy homeostasis. However, the gene regulatory network of the liver after cold exposure remains poorly understood. In this study, we found that 24 h cold exposure (COLD, 6 °C) increased plasma glucose (GLU) levels, while reducing plasma...
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/14330 |
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| author | Duo Su Tianhui Zhou Yan Wang Linjie Wang |
| author_facet | Duo Su Tianhui Zhou Yan Wang Linjie Wang |
| author_sort | Duo Su |
| collection | DOAJ |
| description | Cold exposure influences liver metabolism, thereby affecting energy homeostasis. However, the gene regulatory network of the liver after cold exposure remains poorly understood. In this study, we found that 24 h cold exposure (COLD, 6 °C) increased plasma glucose (GLU) levels, while reducing plasma non-esterified fatty acid (NEFA) and triglyceride (TG) levels compared to the room temperature (RT, 25 °C) group. Cold exposure increased hepatic glycogen content and decreased hepatic lipid content in the livers of newborn goats. We conducted RNA-seq analysis on the livers of newborn goats in both the RT and cold exposure groups. A total of 1600 genes were identified as differentially expressed genes (DEGs), of which 555 genes were up-regulated and 1045 genes were down-regulated in the cold exposure group compared with the RT group. Cold exposure increased the expression of genes involved in glycolysis, glycogen synthesis, and fatty acid degradation pathways. These results can provide a reference for hepatic lipid and glycogen metabolism in newborn goats after cold exposure. |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:39:20Z |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-95e4a8fa0ca64e40b1d7d0cb745b750d2023-11-19T11:11:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181433010.3390/ijms241814330Cold Exposure Regulates Hepatic Glycogen and Lipid Metabolism in Newborn GoatsDuo Su0Tianhui Zhou1Yan Wang2Linjie Wang3Key Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaFarm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, ChinaKey Laboratory of Livestock and Poultry Multi-Omics, Ministry of Agriculture and Rural Affairs, College of Animal and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCold exposure influences liver metabolism, thereby affecting energy homeostasis. However, the gene regulatory network of the liver after cold exposure remains poorly understood. In this study, we found that 24 h cold exposure (COLD, 6 °C) increased plasma glucose (GLU) levels, while reducing plasma non-esterified fatty acid (NEFA) and triglyceride (TG) levels compared to the room temperature (RT, 25 °C) group. Cold exposure increased hepatic glycogen content and decreased hepatic lipid content in the livers of newborn goats. We conducted RNA-seq analysis on the livers of newborn goats in both the RT and cold exposure groups. A total of 1600 genes were identified as differentially expressed genes (DEGs), of which 555 genes were up-regulated and 1045 genes were down-regulated in the cold exposure group compared with the RT group. Cold exposure increased the expression of genes involved in glycolysis, glycogen synthesis, and fatty acid degradation pathways. These results can provide a reference for hepatic lipid and glycogen metabolism in newborn goats after cold exposure.https://www.mdpi.com/1422-0067/24/18/14330cold exposureglycogen metabolismgoatslipid metabolismliver |
| spellingShingle | Duo Su Tianhui Zhou Yan Wang Linjie Wang Cold Exposure Regulates Hepatic Glycogen and Lipid Metabolism in Newborn Goats International Journal of Molecular Sciences cold exposure glycogen metabolism goats lipid metabolism liver |
| title | Cold Exposure Regulates Hepatic Glycogen and Lipid Metabolism in Newborn Goats |
| title_full | Cold Exposure Regulates Hepatic Glycogen and Lipid Metabolism in Newborn Goats |
| title_fullStr | Cold Exposure Regulates Hepatic Glycogen and Lipid Metabolism in Newborn Goats |
| title_full_unstemmed | Cold Exposure Regulates Hepatic Glycogen and Lipid Metabolism in Newborn Goats |
| title_short | Cold Exposure Regulates Hepatic Glycogen and Lipid Metabolism in Newborn Goats |
| title_sort | cold exposure regulates hepatic glycogen and lipid metabolism in newborn goats |
| topic | cold exposure glycogen metabolism goats lipid metabolism liver |
| url | https://www.mdpi.com/1422-0067/24/18/14330 |
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