Substrate specificity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer
The substrate specifity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer has been investigated. Cathepsin H from untransformed tissues of mammary gland hydrolyzed synthetic substrates in a row: Bz-Gly-Phe-...
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| Format: | Article |
| Language: | English |
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Taras Shevchenko National University of Kyiv
2016-07-01
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| Series: | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ |
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| Online Access: | http://biovestnik.com/index.php/biology/article/view/54 |
| Summary: | The substrate specifity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer has been investigated. Cathepsin H from untransformed tissues of mammary gland hydrolyzed synthetic substrates in a row: Bz-Gly-Phe--->Z-Phe-Ala--->Z-Glu-
Tyr--->oxytocin unlike enzyme from malignant tumor that did not hydrolyze the synthetic dipeptide Z-Glu-Tyr and revealed the substrate specificity in a row: Z-Phe-Ala--->Bz-Gly-Phe--->oxytocin. Cathepsin H has proteolytic endopeptidase activity to the substrate casein more pronounced for enzyme from untransformed tissue of mammary gland. |
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| ISSN: | 1728-2748 2308-8036 |