Substrate specificity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer
The substrate specifity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer has been investigated. Cathepsin H from untransformed tissues of mammary gland hydrolyzed synthetic substrates in a row: Bz-Gly-Phe-...
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| Format: | Article |
| Language: | English |
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Taras Shevchenko National University of Kyiv
2016-07-01
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| Series: | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ |
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| Online Access: | http://biovestnik.com/index.php/biology/article/view/54 |
| _version_ | 1797709353749315584 |
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| author | G. Labunets |
| author_facet | G. Labunets |
| author_sort | G. Labunets |
| collection | DOAJ |
| description | The substrate specifity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer has been investigated. Cathepsin H from untransformed tissues of mammary gland hydrolyzed synthetic substrates in a row: Bz-Gly-Phe--->Z-Phe-Ala--->Z-Glu-
Tyr--->oxytocin unlike enzyme from malignant tumor that did not hydrolyze the synthetic dipeptide Z-Glu-Tyr and revealed the substrate specificity in a row: Z-Phe-Ala--->Bz-Gly-Phe--->oxytocin. Cathepsin H has proteolytic endopeptidase activity to the substrate casein more pronounced for enzyme from untransformed tissue of mammary gland. |
| first_indexed | 2024-03-12T06:35:15Z |
| format | Article |
| id | doaj.art-95e4bdc1663f470e90dfb7a8e77322e6 |
| institution | Directory Open Access Journal |
| issn | 1728-2748 2308-8036 |
| language | English |
| last_indexed | 2024-03-12T06:35:15Z |
| publishDate | 2016-07-01 |
| publisher | Taras Shevchenko National University of Kyiv |
| record_format | Article |
| series | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ |
| spelling | doaj.art-95e4bdc1663f470e90dfb7a8e77322e62023-09-03T01:21:16ZengTaras Shevchenko National University of KyivVìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ1728-27482308-80362016-07-01702505210.17721/1728_2748.2015.70.50-5254Substrate specificity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancerG. Labunets0Odessa National Mechnikov University, OdessaThe substrate specifity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer has been investigated. Cathepsin H from untransformed tissues of mammary gland hydrolyzed synthetic substrates in a row: Bz-Gly-Phe--->Z-Phe-Ala--->Z-Glu- Tyr--->oxytocin unlike enzyme from malignant tumor that did not hydrolyze the synthetic dipeptide Z-Glu-Tyr and revealed the substrate specificity in a row: Z-Phe-Ala--->Bz-Gly-Phe--->oxytocin. Cathepsin H has proteolytic endopeptidase activity to the substrate casein more pronounced for enzyme from untransformed tissue of mammary gland.http://biovestnik.com/index.php/biology/article/view/54cathepsin H, tumor, mammary gland, substrate specifity |
| spellingShingle | G. Labunets Substrate specificity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ cathepsin H, tumor, mammary gland, substrate specifity |
| title | Substrate specificity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer |
| title_full | Substrate specificity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer |
| title_fullStr | Substrate specificity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer |
| title_full_unstemmed | Substrate specificity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer |
| title_short | Substrate specificity of cathepsin H in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer |
| title_sort | substrate specificity of cathepsin h in untransformed tissues of mammary gland and in tissues of moderately differentiated form of lobular infiltrating breast cancer |
| topic | cathepsin H, tumor, mammary gland, substrate specifity |
| url | http://biovestnik.com/index.php/biology/article/view/54 |
| work_keys_str_mv | AT glabunets substratespecificityofcathepsinhinuntransformedtissuesofmammaryglandandintissuesofmoderatelydifferentiatedformoflobularinfiltratingbreastcancer |