Crebanine N-oxide, a natural aporphine alkaloid isolated from Stephania hainanensis, induces apoptosis and autophagy in human gastric cancer SGC-7901 cells

Crebanine N-oxide, a natural aporphine alkaloid isolated from Stephania hainanensis, induces apoptosis and autophagy in human gastric cancer SGC-7901 cells

Objective: To investigate the cytotoxic effects and the potential mechanisms of crebanine N-oxide in SGC-7901 gastric adenocarcinoma cells. Methods: The cytotoxicity of crebanine N-oxide was evaluated by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay and cellular morphology...

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Bibliographic Details
Main Authors: Zheng-Wen Wang, Hao Liu, Geng-Tai Ye, Zhi-Yong Sheng, Yan-Feng Hu, Yin-Feng Tan, Guo-Xin Li
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
crebanine n-oxide; gastric cancer; sgc-7901 cells; apoptosis; autophagy
Online Access:http://www.apjtb.org/article.asp?issn=2221-1691;year=2020;volume=10;issue=5;spage=224;epage=231;aulast=Wang

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