Interactions of pathogenic Escherichia coli with CEACAMs
The pathogenic Escherichia coli can be parsed into specific variants (pathovars) depending on their phenotypic behavior and/or expression of specific virulence factors. These pathogens are built around chromosomally-encoded core attributes and through acquisition of specific virulence genes that dir...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1120331/full |
| _version_ | 1811164253017604096 |
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| author | Alaullah Sheikh James M. Fleckenstein James M. Fleckenstein |
| author_facet | Alaullah Sheikh James M. Fleckenstein James M. Fleckenstein |
| author_sort | Alaullah Sheikh |
| collection | DOAJ |
| description | The pathogenic Escherichia coli can be parsed into specific variants (pathovars) depending on their phenotypic behavior and/or expression of specific virulence factors. These pathogens are built around chromosomally-encoded core attributes and through acquisition of specific virulence genes that direct their interaction with the host. Engagement of E. coli pathovars with CEACAMs is determined both by core elements common to all E. coli as well as extrachromosomally-encoded pathovar-specific virulence traits, which target amino terminal immunoglobulin variable-like (IgV) regions of CEACAMs. Emerging data suggests that engagement of CEACAMs does not unilaterally benefit the pathogen and that these interactions may also provide an avenue for pathogen elimination. |
| first_indexed | 2024-04-10T15:18:29Z |
| format | Article |
| id | doaj.art-95e9355591f949a591a8e1db576f9f6b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T15:18:29Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-95e9355591f949a591a8e1db576f9f6b2023-02-14T17:16:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.11203311120331Interactions of pathogenic Escherichia coli with CEACAMsAlaullah Sheikh0James M. Fleckenstein1James M. Fleckenstein2Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United StatesDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United StatesInfectious Diseases, Medicine Service, Veterans Affairs Saint Louis Health Care System, Saint Louis, MO, United StatesThe pathogenic Escherichia coli can be parsed into specific variants (pathovars) depending on their phenotypic behavior and/or expression of specific virulence factors. These pathogens are built around chromosomally-encoded core attributes and through acquisition of specific virulence genes that direct their interaction with the host. Engagement of E. coli pathovars with CEACAMs is determined both by core elements common to all E. coli as well as extrachromosomally-encoded pathovar-specific virulence traits, which target amino terminal immunoglobulin variable-like (IgV) regions of CEACAMs. Emerging data suggests that engagement of CEACAMs does not unilaterally benefit the pathogen and that these interactions may also provide an avenue for pathogen elimination.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1120331/fullEscherichia coliETEC (enterotoxigenic Escherichia coli)CEACAMAfa/dr family adhesinstype 1 fimbriae |
| spellingShingle | Alaullah Sheikh James M. Fleckenstein James M. Fleckenstein Interactions of pathogenic Escherichia coli with CEACAMs Frontiers in Immunology Escherichia coli ETEC (enterotoxigenic Escherichia coli) CEACAM Afa/dr family adhesins type 1 fimbriae |
| title | Interactions of pathogenic Escherichia coli with CEACAMs |
| title_full | Interactions of pathogenic Escherichia coli with CEACAMs |
| title_fullStr | Interactions of pathogenic Escherichia coli with CEACAMs |
| title_full_unstemmed | Interactions of pathogenic Escherichia coli with CEACAMs |
| title_short | Interactions of pathogenic Escherichia coli with CEACAMs |
| title_sort | interactions of pathogenic escherichia coli with ceacams |
| topic | Escherichia coli ETEC (enterotoxigenic Escherichia coli) CEACAM Afa/dr family adhesins type 1 fimbriae |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1120331/full |
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