Recent Advances in Next Generation Snakebite Antivenoms
With the inclusion of snakebite envenoming on the World Health Organization’s list of Neglected Tropical Diseases, an incentive has been established to promote research and development effort in novel snakebite antivenom therapies. Various technological approaches are being pursued by different rese...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-04-01
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| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2414-6366/3/2/42 |
| _version_ | 1811262491212120064 |
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| author | Cecilie Knudsen Andreas H. Laustsen |
| author_facet | Cecilie Knudsen Andreas H. Laustsen |
| author_sort | Cecilie Knudsen |
| collection | DOAJ |
| description | With the inclusion of snakebite envenoming on the World Health Organization’s list of Neglected Tropical Diseases, an incentive has been established to promote research and development effort in novel snakebite antivenom therapies. Various technological approaches are being pursued by different research groups, including the use of small molecule inhibitors against enzymatic toxins as well as peptide- and oligonucleotide-based aptamers and antibody-based biotherapeutics against both enzymatic and non-enzymatic toxins. In this article, the most recent advances in these fields are presented, and the advantages, disadvantages, and feasibility of using different toxin-neutralizing molecules are reviewed. Particular focus within small molecules is directed towards the inhibitors varespladib, batimastat, and marimastat, while in the field of antibody-based therapies, novel recombinant polyclonal plantivenom technology is discussed. |
| first_indexed | 2024-04-12T19:26:28Z |
| format | Article |
| id | doaj.art-95ead9805fa44237a04cbbc08edff5ee |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-04-12T19:26:28Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-95ead9805fa44237a04cbbc08edff5ee2022-12-22T03:19:28ZengMDPI AGTropical Medicine and Infectious Disease2414-63662018-04-01324210.3390/tropicalmed3020042tropicalmed3020042Recent Advances in Next Generation Snakebite AntivenomsCecilie Knudsen0Andreas H. Laustsen1Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, DK-2800, DenmarkDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, DK-2800, DenmarkWith the inclusion of snakebite envenoming on the World Health Organization’s list of Neglected Tropical Diseases, an incentive has been established to promote research and development effort in novel snakebite antivenom therapies. Various technological approaches are being pursued by different research groups, including the use of small molecule inhibitors against enzymatic toxins as well as peptide- and oligonucleotide-based aptamers and antibody-based biotherapeutics against both enzymatic and non-enzymatic toxins. In this article, the most recent advances in these fields are presented, and the advantages, disadvantages, and feasibility of using different toxin-neutralizing molecules are reviewed. Particular focus within small molecules is directed towards the inhibitors varespladib, batimastat, and marimastat, while in the field of antibody-based therapies, novel recombinant polyclonal plantivenom technology is discussed.http://www.mdpi.com/2414-6366/3/2/42antivenomsnakebitesmall molecule toxin inhibitorsoligonucleotidesantibodiesphage displaynext generation antivenomrecombinant antivenom |
| spellingShingle | Cecilie Knudsen Andreas H. Laustsen Recent Advances in Next Generation Snakebite Antivenoms Tropical Medicine and Infectious Disease antivenom snakebite small molecule toxin inhibitors oligonucleotides antibodies phage display next generation antivenom recombinant antivenom |
| title | Recent Advances in Next Generation Snakebite Antivenoms |
| title_full | Recent Advances in Next Generation Snakebite Antivenoms |
| title_fullStr | Recent Advances in Next Generation Snakebite Antivenoms |
| title_full_unstemmed | Recent Advances in Next Generation Snakebite Antivenoms |
| title_short | Recent Advances in Next Generation Snakebite Antivenoms |
| title_sort | recent advances in next generation snakebite antivenoms |
| topic | antivenom snakebite small molecule toxin inhibitors oligonucleotides antibodies phage display next generation antivenom recombinant antivenom |
| url | http://www.mdpi.com/2414-6366/3/2/42 |
| work_keys_str_mv | AT cecilieknudsen recentadvancesinnextgenerationsnakebiteantivenoms AT andreashlaustsen recentadvancesinnextgenerationsnakebiteantivenoms |