Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy
As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/11/2878 |
| _version_ | 1797510876540960768 |
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| author | Aditya Bhalerao Snehal Raut Behnam Noorani Salvatore Mancuso Luca Cucullo |
| author_facet | Aditya Bhalerao Snehal Raut Behnam Noorani Salvatore Mancuso Luca Cucullo |
| author_sort | Aditya Bhalerao |
| collection | DOAJ |
| description | As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests itself in the form of severe respiratory distress, it is also known to cause systemic damage to almost all major organs and organ systems within the body. In this review, we discuss the molecular mechanisms leading to multi-organ failure seen in COVID-19 patients. We also examine the potential of stem cell therapy in treating COVID-19 multi-organ failure cases. |
| first_indexed | 2024-03-10T05:37:32Z |
| format | Article |
| id | doaj.art-95ec41c5284d4e9c98b2bd05700c4b69 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:37:32Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-95ec41c5284d4e9c98b2bd05700c4b692023-11-22T22:48:04ZengMDPI AGCells2073-44092021-10-011011287810.3390/cells10112878Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell TherapyAditya Bhalerao0Snehal Raut1Behnam Noorani2Salvatore Mancuso3Luca Cucullo4Department of Biological and Biomedical Sciences, Oakland University, Rochester, MI 48309, USADepartment of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USADepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USADepartment of Biological and Biomedical Sciences, Oakland University, Rochester, MI 48309, USADepartment of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USAAs the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests itself in the form of severe respiratory distress, it is also known to cause systemic damage to almost all major organs and organ systems within the body. In this review, we discuss the molecular mechanisms leading to multi-organ failure seen in COVID-19 patients. We also examine the potential of stem cell therapy in treating COVID-19 multi-organ failure cases.https://www.mdpi.com/2073-4409/10/11/2878SARS-CoV-2COVID-19stem cellsmesenchymaltherapeuticsregenerative |
| spellingShingle | Aditya Bhalerao Snehal Raut Behnam Noorani Salvatore Mancuso Luca Cucullo Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy Cells SARS-CoV-2 COVID-19 stem cells mesenchymal therapeutics regenerative |
| title | Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy |
| title_full | Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy |
| title_fullStr | Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy |
| title_full_unstemmed | Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy |
| title_short | Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy |
| title_sort | molecular mechanisms of multi organ failure in covid 19 and potential of stem cell therapy |
| topic | SARS-CoV-2 COVID-19 stem cells mesenchymal therapeutics regenerative |
| url | https://www.mdpi.com/2073-4409/10/11/2878 |
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