The Oxepane Motif in Marine Drugs
Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-11-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/15/11/361 |
| _version_ | 1798026782715150336 |
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| author | Héctor Barbero Carlos Díez-Poza Asunción Barbero |
| author_facet | Héctor Barbero Carlos Díez-Poza Asunción Barbero |
| author_sort | Héctor Barbero |
| collection | DOAJ |
| description | Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungus and corals and show very important biological activities, many of them possessing remarkable cytotoxic properties against a wide range of cancer cell lines. Their rich chemical structures have attracted the attention of many researchers who have reported interesting synthetic approaches to these targets. This review covers the most prominent examples of these types of compounds, focusing the discussion on the isolation, structure determination, medicinal properties and total synthesis of these products. |
| first_indexed | 2024-04-11T18:40:52Z |
| format | Article |
| id | doaj.art-95edb243163b4e259cbf80d07068f7d5 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T18:40:52Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-95edb243163b4e259cbf80d07068f7d52022-12-22T04:08:59ZengMDPI AGMarine Drugs1660-33972017-11-01151136110.3390/md15110361md15110361The Oxepane Motif in Marine DrugsHéctor Barbero0Carlos Díez-Poza1Asunción Barbero2GIR MIOMeT, IU CINQUIMA/Inorganic Chemistry, University of Valladolid, Campus Miguel Delibes, 47011 Valladolid, SpainDepartment of Organic Chemistry, University of Valladolid, Campus Miguel Delibes, 47011 Valladolid, SpainDepartment of Organic Chemistry, University of Valladolid, Campus Miguel Delibes, 47011 Valladolid, SpainOceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungus and corals and show very important biological activities, many of them possessing remarkable cytotoxic properties against a wide range of cancer cell lines. Their rich chemical structures have attracted the attention of many researchers who have reported interesting synthetic approaches to these targets. This review covers the most prominent examples of these types of compounds, focusing the discussion on the isolation, structure determination, medicinal properties and total synthesis of these products.https://www.mdpi.com/1660-3397/15/11/361marine drugsoxepanestotal synthesisbiological activity |
| spellingShingle | Héctor Barbero Carlos Díez-Poza Asunción Barbero The Oxepane Motif in Marine Drugs Marine Drugs marine drugs oxepanes total synthesis biological activity |
| title | The Oxepane Motif in Marine Drugs |
| title_full | The Oxepane Motif in Marine Drugs |
| title_fullStr | The Oxepane Motif in Marine Drugs |
| title_full_unstemmed | The Oxepane Motif in Marine Drugs |
| title_short | The Oxepane Motif in Marine Drugs |
| title_sort | oxepane motif in marine drugs |
| topic | marine drugs oxepanes total synthesis biological activity |
| url | https://www.mdpi.com/1660-3397/15/11/361 |
| work_keys_str_mv | AT hectorbarbero theoxepanemotifinmarinedrugs AT carlosdiezpoza theoxepanemotifinmarinedrugs AT asuncionbarbero theoxepanemotifinmarinedrugs AT hectorbarbero oxepanemotifinmarinedrugs AT carlosdiezpoza oxepanemotifinmarinedrugs AT asuncionbarbero oxepanemotifinmarinedrugs |