Breast cancer liver metastasis: Pathogenesis and clinical implications
Breast cancer is the most common malignant disease in female patients worldwide and can spread to almost every place in the human body, most frequently metastasizing to lymph nodes, bones, lungs, liver and brain. The liver is a common metastatic location for solid cancers as a whole, and it is also...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1043771/full |
| _version_ | 1828142486177972224 |
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| author | Cuiwei Liu Srivarshini C. Mohan Jielin Wei Ekihiro Seki Manran Liu Reva Basho Reva Basho Armando E. Giuliano Yanxia Zhao Xiaojiang Cui |
| author_facet | Cuiwei Liu Srivarshini C. Mohan Jielin Wei Ekihiro Seki Manran Liu Reva Basho Reva Basho Armando E. Giuliano Yanxia Zhao Xiaojiang Cui |
| author_sort | Cuiwei Liu |
| collection | DOAJ |
| description | Breast cancer is the most common malignant disease in female patients worldwide and can spread to almost every place in the human body, most frequently metastasizing to lymph nodes, bones, lungs, liver and brain. The liver is a common metastatic location for solid cancers as a whole, and it is also the third most common metastatic site for breast cancer. Breast cancer liver metastasis (BCLM) is a complex process. Although the hepatic microenvironment and liver sinusoidal structure are crucial factors for the initial arrest of breast cancer and progression within the liver, the biological basis of BCLM remains to be elucidated. Importantly, further understanding of the interaction between breast cancer cells and hepatic microenvironment in the liver metastasis of breast cancer will suggest ways for the development of effective therapy and prevention strategies for BCLM. In this review, we provide an overview of the recent advances in the understanding of the molecular mechanisms of the hepatic microenvironment in BCLM formation and discuss current systemic therapies for treating patients with BCLM as well as potential therapeutic development based on the liver microenvironment-associated signaling proteins governing BCLM. |
| first_indexed | 2024-04-11T19:41:56Z |
| format | Article |
| id | doaj.art-95edbc86b6644f948804c051030053b9 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T19:41:56Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-95edbc86b6644f948804c051030053b92022-12-22T04:06:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.10437711043771Breast cancer liver metastasis: Pathogenesis and clinical implicationsCuiwei Liu0Srivarshini C. Mohan1Jielin Wei2Ekihiro Seki3Manran Liu4Reva Basho5Reva Basho6Armando E. Giuliano7Yanxia Zhao8Xiaojiang Cui9Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesKey Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education, Chongqing Medical University, Chongqing, ChinaDepartment of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesThe Lawrence J. Ellison Institute for Transformative Medicine, Los Angeles, CA, United StatesDepartment of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United StatesBreast cancer is the most common malignant disease in female patients worldwide and can spread to almost every place in the human body, most frequently metastasizing to lymph nodes, bones, lungs, liver and brain. The liver is a common metastatic location for solid cancers as a whole, and it is also the third most common metastatic site for breast cancer. Breast cancer liver metastasis (BCLM) is a complex process. Although the hepatic microenvironment and liver sinusoidal structure are crucial factors for the initial arrest of breast cancer and progression within the liver, the biological basis of BCLM remains to be elucidated. Importantly, further understanding of the interaction between breast cancer cells and hepatic microenvironment in the liver metastasis of breast cancer will suggest ways for the development of effective therapy and prevention strategies for BCLM. In this review, we provide an overview of the recent advances in the understanding of the molecular mechanisms of the hepatic microenvironment in BCLM formation and discuss current systemic therapies for treating patients with BCLM as well as potential therapeutic development based on the liver microenvironment-associated signaling proteins governing BCLM.https://www.frontiersin.org/articles/10.3389/fonc.2022.1043771/fullliver metastasispathogenesisclinical implicationsbreast cancerhepatic microenvironment |
| spellingShingle | Cuiwei Liu Srivarshini C. Mohan Jielin Wei Ekihiro Seki Manran Liu Reva Basho Reva Basho Armando E. Giuliano Yanxia Zhao Xiaojiang Cui Breast cancer liver metastasis: Pathogenesis and clinical implications Frontiers in Oncology liver metastasis pathogenesis clinical implications breast cancer hepatic microenvironment |
| title | Breast cancer liver metastasis: Pathogenesis and clinical implications |
| title_full | Breast cancer liver metastasis: Pathogenesis and clinical implications |
| title_fullStr | Breast cancer liver metastasis: Pathogenesis and clinical implications |
| title_full_unstemmed | Breast cancer liver metastasis: Pathogenesis and clinical implications |
| title_short | Breast cancer liver metastasis: Pathogenesis and clinical implications |
| title_sort | breast cancer liver metastasis pathogenesis and clinical implications |
| topic | liver metastasis pathogenesis clinical implications breast cancer hepatic microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1043771/full |
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