Maintained high sustained serum malondialdehyde levels after severe brain trauma injury in non-survivor patients
Abstract Objective Higher blood malondialdehyde (biomarker of lipid peroxidation) levels in the first hours of traumatic brain injury (TBI) have been found in patients with a worst prognosis. The objective of this study was to determine whether serum malondialdehyde levels during the first week of s...
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BMC
2019-12-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-019-4828-5 |
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| author | Leonardo Lorente María M. Martín Pedro Abreu-González Luis Ramos Juan J. Cáceres Mónica Argueso Jordi Solé-Violán Alejandro Jiménez Victor García-Marín |
| author_facet | Leonardo Lorente María M. Martín Pedro Abreu-González Luis Ramos Juan J. Cáceres Mónica Argueso Jordi Solé-Violán Alejandro Jiménez Victor García-Marín |
| author_sort | Leonardo Lorente |
| collection | DOAJ |
| description | Abstract Objective Higher blood malondialdehyde (biomarker of lipid peroxidation) levels in the first hours of traumatic brain injury (TBI) have been found in patients with a worst prognosis. The objective of this study was to determine whether serum malondialdehyde levels during the first week of severe TBI could be used as mortality biomarkers. This was a multicenter, prospective and observational study performed in six Spanish Intensive Care Units. We included patients with severe TBI (defined as Glasgow Coma Scale < 9), and with Injury Severity Score in non-cranial aspects < 9. We determined serum malondialdehyde concentrations at days 1, 4 and 8 of TBI. We stablished 30-day mortality as the end-point study. Results We found that serum malondialdehyde concentrations at days 1 (p < 0.001), 4 (p < 0.001), and 8 (p < 0.001) of TBI were higher in non-survivor (n = 34) than in survivor (n = 90) patients. We found an area under curve of serum malondialdehyde concentrations at days 1, 4, and 8 of TBI to predict 30-day mortality of 77% (p < 0.001), 87% (p < 0.001) and 84% (p < 0.001) respectively. Thus, the new and most relevant findings of our study were serum malondialdehyde levels during the first week of TBI could be used as mortality biomarkers. |
| first_indexed | 2024-12-20T02:47:34Z |
| format | Article |
| id | doaj.art-95edd93b9335475db1650ff870d71cfc |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-20T02:47:34Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-95edd93b9335475db1650ff870d71cfc2022-12-21T19:56:07ZengBMCBMC Research Notes1756-05002019-12-011211510.1186/s13104-019-4828-5Maintained high sustained serum malondialdehyde levels after severe brain trauma injury in non-survivor patientsLeonardo Lorente0María M. Martín1Pedro Abreu-González2Luis Ramos3Juan J. Cáceres4Mónica Argueso5Jordi Solé-Violán6Alejandro Jiménez7Victor García-Marín8Intensive Care Unit, Hospital Universitario de Canarias, OfraIntensive Care Unit, Hospital Universitario Nuestra Señora de CandelariaDeparment of Phisiology, Faculty of Medicine, University of the La LagunaIntensive Care Unit, Hospital General La PalmaIntensive Care Unit, Hospital InsularIntensive Care Unit, Hospital Clínico Universitario de ValenciaIntensive Care Unit, Hospital Universitario Dr. Negrín, CIBERESResearch Unit, Hospital Universitario de Canarias, OfraDeparment of Neurosurgery Hospital, Universitario de Canarias, OfraAbstract Objective Higher blood malondialdehyde (biomarker of lipid peroxidation) levels in the first hours of traumatic brain injury (TBI) have been found in patients with a worst prognosis. The objective of this study was to determine whether serum malondialdehyde levels during the first week of severe TBI could be used as mortality biomarkers. This was a multicenter, prospective and observational study performed in six Spanish Intensive Care Units. We included patients with severe TBI (defined as Glasgow Coma Scale < 9), and with Injury Severity Score in non-cranial aspects < 9. We determined serum malondialdehyde concentrations at days 1, 4 and 8 of TBI. We stablished 30-day mortality as the end-point study. Results We found that serum malondialdehyde concentrations at days 1 (p < 0.001), 4 (p < 0.001), and 8 (p < 0.001) of TBI were higher in non-survivor (n = 34) than in survivor (n = 90) patients. We found an area under curve of serum malondialdehyde concentrations at days 1, 4, and 8 of TBI to predict 30-day mortality of 77% (p < 0.001), 87% (p < 0.001) and 84% (p < 0.001) respectively. Thus, the new and most relevant findings of our study were serum malondialdehyde levels during the first week of TBI could be used as mortality biomarkers.https://doi.org/10.1186/s13104-019-4828-5MalondialdehydeBrain traumaPatientsMortalityInjury |
| spellingShingle | Leonardo Lorente María M. Martín Pedro Abreu-González Luis Ramos Juan J. Cáceres Mónica Argueso Jordi Solé-Violán Alejandro Jiménez Victor García-Marín Maintained high sustained serum malondialdehyde levels after severe brain trauma injury in non-survivor patients BMC Research Notes Malondialdehyde Brain trauma Patients Mortality Injury |
| title | Maintained high sustained serum malondialdehyde levels after severe brain trauma injury in non-survivor patients |
| title_full | Maintained high sustained serum malondialdehyde levels after severe brain trauma injury in non-survivor patients |
| title_fullStr | Maintained high sustained serum malondialdehyde levels after severe brain trauma injury in non-survivor patients |
| title_full_unstemmed | Maintained high sustained serum malondialdehyde levels after severe brain trauma injury in non-survivor patients |
| title_short | Maintained high sustained serum malondialdehyde levels after severe brain trauma injury in non-survivor patients |
| title_sort | maintained high sustained serum malondialdehyde levels after severe brain trauma injury in non survivor patients |
| topic | Malondialdehyde Brain trauma Patients Mortality Injury |
| url | https://doi.org/10.1186/s13104-019-4828-5 |
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