IgG4-related ophthalmic disease masquerading as ciliary body tumors and scleritis in both eyes: a case report
Abstract Background To report a rare case of IgG4-related ophthalmic disease (IgG4-ROD) manifesting as intraocular masses and scleritis in both eyes in a 61-year-old male and to investigate the changes in multimodal imaging features of the lesion sites and helper T-cell type 1 (Th 1)/Th 2/Th 17 cyto...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-023-02822-7 |
| _version_ | 1797865259900338176 |
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| author | Jiayue Ma Manyun Xie Kejun Long Mi Deng Liang Zhou Jing Luo |
| author_facet | Jiayue Ma Manyun Xie Kejun Long Mi Deng Liang Zhou Jing Luo |
| author_sort | Jiayue Ma |
| collection | DOAJ |
| description | Abstract Background To report a rare case of IgG4-related ophthalmic disease (IgG4-ROD) manifesting as intraocular masses and scleritis in both eyes in a 61-year-old male and to investigate the changes in multimodal imaging features of the lesion sites and helper T-cell type 1 (Th 1)/Th 2/Th 17 cytokine levels in the aqueous humor. Case presentation A patient with IgG4-ROD seemingly manifested with an intraocular tumor in the left eye and sequentially, with an inflammatory mass in the ciliary body and scleritis in the right eye. The patient complained of vision loss of 6 months duration in the left eye at his first visit. With a preliminary diagnosis of an intraocular tumor, enucleation of the left eyeball and histopathological examination were performed. Approximately 3 months later, the patient started to experience headache, eye pain, and declining vision in the right eye. Ophthalmic imaging revealed a ciliary mass and scleritis. Th 1/Th 2/Th 17 cytokine levels and multimodal imaging findings were analyzed before and after corticosteroid treatment. Histopathological examination and immunohistochemistry (IHC) of the enucleated left eye demonstrated lymphoplasmacytic infiltration with an IgG4+/IgG+ cell ratio of approximately 40%, pointing to the diagnosis of probable IgG4-ROD. Long-term treatment with corticosteroids led to significant improvement in the signs and symptoms of the left eye. Th 1/Th 2/Th 17 cytokine profile monitoring of the aqueous humor and multimodal imaging of the right eye showed gradual regression of the mass and attenuation of ocular inflammation during treatment. Conclusions Patients with an atypical presentation of IgG4-ROD, such as intraocular masses and scleritis, are likely to experience a significant delay in diagnosis. This case demonstrates the significance of IgG4-ROD in the differential diagnosis of intraocular tumors and ocular inflammation. IgG4-RD is a newly diagnosed disease with multi-organ involvement and little is known about its pathogenesis, particularly in the eye. The present case will open new challenges in the clinico-pathological diagnosis and research of this disease. Combined investigations of multimodal imaging and cytokine level detection of intraocular fluid provide a new and effective way to monitor disease progression. |
| first_indexed | 2024-04-09T23:05:26Z |
| format | Article |
| id | doaj.art-95ef0d5444404760ba9d34379ffd9588 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-09T23:05:26Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-95ef0d5444404760ba9d34379ffd95882023-03-22T10:44:13ZengBMCBMC Ophthalmology1471-24152023-03-012311910.1186/s12886-023-02822-7IgG4-related ophthalmic disease masquerading as ciliary body tumors and scleritis in both eyes: a case reportJiayue Ma0Manyun Xie1Kejun Long2Mi Deng3Liang Zhou4Jing Luo5Department of Ophthalmology, The Second Xiangya Hospital, Central South UniversityDepartment of Ophthalmology, The Second Xiangya Hospital, Central South UniversityDepartment of Ophthalmology, The Second Xiangya Hospital, Central South UniversityDepartment of Ophthalmology, The Second Xiangya Hospital, Central South UniversityDepartment of Ophthalmology, The Second Xiangya Hospital, Central South UniversityDepartment of Ophthalmology, The Second Xiangya Hospital, Central South UniversityAbstract Background To report a rare case of IgG4-related ophthalmic disease (IgG4-ROD) manifesting as intraocular masses and scleritis in both eyes in a 61-year-old male and to investigate the changes in multimodal imaging features of the lesion sites and helper T-cell type 1 (Th 1)/Th 2/Th 17 cytokine levels in the aqueous humor. Case presentation A patient with IgG4-ROD seemingly manifested with an intraocular tumor in the left eye and sequentially, with an inflammatory mass in the ciliary body and scleritis in the right eye. The patient complained of vision loss of 6 months duration in the left eye at his first visit. With a preliminary diagnosis of an intraocular tumor, enucleation of the left eyeball and histopathological examination were performed. Approximately 3 months later, the patient started to experience headache, eye pain, and declining vision in the right eye. Ophthalmic imaging revealed a ciliary mass and scleritis. Th 1/Th 2/Th 17 cytokine levels and multimodal imaging findings were analyzed before and after corticosteroid treatment. Histopathological examination and immunohistochemistry (IHC) of the enucleated left eye demonstrated lymphoplasmacytic infiltration with an IgG4+/IgG+ cell ratio of approximately 40%, pointing to the diagnosis of probable IgG4-ROD. Long-term treatment with corticosteroids led to significant improvement in the signs and symptoms of the left eye. Th 1/Th 2/Th 17 cytokine profile monitoring of the aqueous humor and multimodal imaging of the right eye showed gradual regression of the mass and attenuation of ocular inflammation during treatment. Conclusions Patients with an atypical presentation of IgG4-ROD, such as intraocular masses and scleritis, are likely to experience a significant delay in diagnosis. This case demonstrates the significance of IgG4-ROD in the differential diagnosis of intraocular tumors and ocular inflammation. IgG4-RD is a newly diagnosed disease with multi-organ involvement and little is known about its pathogenesis, particularly in the eye. The present case will open new challenges in the clinico-pathological diagnosis and research of this disease. Combined investigations of multimodal imaging and cytokine level detection of intraocular fluid provide a new and effective way to monitor disease progression.https://doi.org/10.1186/s12886-023-02822-7Immunoglobulin G4-related ophthalmic diseaseAutoimmune diseaseOphthalmic imagingOcular tumorScleritisCytokine level |
| spellingShingle | Jiayue Ma Manyun Xie Kejun Long Mi Deng Liang Zhou Jing Luo IgG4-related ophthalmic disease masquerading as ciliary body tumors and scleritis in both eyes: a case report BMC Ophthalmology Immunoglobulin G4-related ophthalmic disease Autoimmune disease Ophthalmic imaging Ocular tumor Scleritis Cytokine level |
| title | IgG4-related ophthalmic disease masquerading as ciliary body tumors and scleritis in both eyes: a case report |
| title_full | IgG4-related ophthalmic disease masquerading as ciliary body tumors and scleritis in both eyes: a case report |
| title_fullStr | IgG4-related ophthalmic disease masquerading as ciliary body tumors and scleritis in both eyes: a case report |
| title_full_unstemmed | IgG4-related ophthalmic disease masquerading as ciliary body tumors and scleritis in both eyes: a case report |
| title_short | IgG4-related ophthalmic disease masquerading as ciliary body tumors and scleritis in both eyes: a case report |
| title_sort | igg4 related ophthalmic disease masquerading as ciliary body tumors and scleritis in both eyes a case report |
| topic | Immunoglobulin G4-related ophthalmic disease Autoimmune disease Ophthalmic imaging Ocular tumor Scleritis Cytokine level |
| url | https://doi.org/10.1186/s12886-023-02822-7 |
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