Investigating Absolute Stereochemical Configuration with Coulomb Explosion Imaging
It is a particularly challenging task in stereochemistry to determine the absolute configuration of chiral molecules, i.e. to assign to a given sample the microscopic enantiomeric structure. In recent years, Coulomb Explosion Imaging (CEI) has been shown to yield directly the absolute conf...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2018-06-01
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| Series: | CHIMIA |
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| Online Access: | https://www.chimia.ch/chimia/article/view/1447 |
| _version_ | 1819278836746944512 |
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| author | Martin Pitzer Robert Berger Jürgen Stohner Reinhard Dörner Markus Schöffler |
| author_facet | Martin Pitzer Robert Berger Jürgen Stohner Reinhard Dörner Markus Schöffler |
| author_sort | Martin Pitzer |
| collection | DOAJ |
| description |
It is a particularly challenging task in stereochemistry to determine the absolute configuration of chiral molecules, i.e. to assign to a given sample the microscopic enantiomeric structure. In recent years, Coulomb Explosion Imaging (CEI) has been shown to yield directly the
absolute configuration of small molecules in the gas phase. This contribution describes the experimental basics of this approach, highlights the most significant results and discusses limitations. A short discussion on extending Coulomb Explosion Imaging beyond analytic aspects to fundamental questions of molecular chirality concludes this review.
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| first_indexed | 2024-12-24T00:18:20Z |
| format | Article |
| id | doaj.art-95f09c3521714eb08d4a12ac5ede69db |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-12-24T00:18:20Z |
| publishDate | 2018-06-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-95f09c3521714eb08d4a12ac5ede69db2022-12-21T17:24:41ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242018-06-0172610.2533/chimia.2018.384Investigating Absolute Stereochemical Configuration with Coulomb Explosion ImagingMartin Pitzer0Robert Berger1Jürgen Stohner2Reinhard Dörner3Markus Schöffler4Institut für Kernphysik, Goethe-Universität Max-von-Laue-Str. 1, 60438 Frankfurt, Germany; Department of Chemical and Biological Physics Weizmann Institute of Science P.O. Box 26, 76100 Rehovot, Israel. martin.pitzer@weizmann.ac.ilPhilipps-Universität Marburg, Fachbereich Chemie Hans-Meerwein-Straße, 35032 Marburg, GermanyZürcher Hochschule für Angewandte Wissenschaften, Campus Reidbach Institut für Chemie und Biotechnologie Einsiedlerstrasse 31, CH-8820 Wädenswil, SwitzerlandInstitut für Kernphysik, Goethe-Universität Max-von-Laue-Str. 1, 60438 Frankfurt, GermanyInstitut für Kernphysik, Goethe-Universität Max-von-Laue-Str. 1, 60438 Frankfurt, Germany. schoeffler@atom.uni-frankfurt.de It is a particularly challenging task in stereochemistry to determine the absolute configuration of chiral molecules, i.e. to assign to a given sample the microscopic enantiomeric structure. In recent years, Coulomb Explosion Imaging (CEI) has been shown to yield directly the absolute configuration of small molecules in the gas phase. This contribution describes the experimental basics of this approach, highlights the most significant results and discusses limitations. A short discussion on extending Coulomb Explosion Imaging beyond analytic aspects to fundamental questions of molecular chirality concludes this review. https://www.chimia.ch/chimia/article/view/1447Absolute configurationChiralityCoincidenceGas-phasePhotoionisation |
| spellingShingle | Martin Pitzer Robert Berger Jürgen Stohner Reinhard Dörner Markus Schöffler Investigating Absolute Stereochemical Configuration with Coulomb Explosion Imaging CHIMIA Absolute configuration Chirality Coincidence Gas-phase Photoionisation |
| title | Investigating Absolute Stereochemical Configuration with Coulomb Explosion Imaging |
| title_full | Investigating Absolute Stereochemical Configuration with Coulomb Explosion Imaging |
| title_fullStr | Investigating Absolute Stereochemical Configuration with Coulomb Explosion Imaging |
| title_full_unstemmed | Investigating Absolute Stereochemical Configuration with Coulomb Explosion Imaging |
| title_short | Investigating Absolute Stereochemical Configuration with Coulomb Explosion Imaging |
| title_sort | investigating absolute stereochemical configuration with coulomb explosion imaging |
| topic | Absolute configuration Chirality Coincidence Gas-phase Photoionisation |
| url | https://www.chimia.ch/chimia/article/view/1447 |
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