Immune Checkpoint PD-1-based Mechanisms of Tumor Immune Resistance and Strategies for Re-treatment After Drug Resistance
Immunotherapy is considered as the fourth cancer treatment after surgery, radiotherapy and chemotherapy. With the in-depth research on immunotherapy in recent years, especially immuno-checkpoint inhibitors, PD-1/PD-L1 pathway inhibitors have been approved for the treatment of many cancer species. Bu...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Magazine House of Cancer Research on Prevention and Treatment
2022-06-01
|
| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.1296 |
| _version_ | 1811326713950371840 |
|---|---|
| author | LI Yuxin JIN Feng |
| author_facet | LI Yuxin JIN Feng |
| author_sort | LI Yuxin |
| collection | DOAJ |
| description | Immunotherapy is considered as the fourth cancer treatment after surgery, radiotherapy and chemotherapy. With the in-depth research on immunotherapy in recent years, especially immuno-checkpoint inhibitors, PD-1/PD-L1 pathway inhibitors have been approved for the treatment of many cancer species. But due to the immune response of tumor cells through multiple drug-resistant mechanisms, immuno-checkpoint blockade has some problems, such as low overall response rate, primary or secondary drug resistance and so on. This paper expounds the mechanism of tumor immune resistance and explores strategies for further treatment after drug resistance, which provides a new theoretical and clinical basis for improving the response rate of immune checkpoint inhibitors and reducing the probability of immune resistance. |
| first_indexed | 2024-04-13T14:54:25Z |
| format | Article |
| id | doaj.art-95f31bf1beb7424882925b003fb083ad |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-04-13T14:54:25Z |
| publishDate | 2022-06-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-95f31bf1beb7424882925b003fb083ad2022-12-22T02:42:29ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782022-06-0149654655110.3971/j.issn.1000-8578.2022.21.12968578.2022.21.1296Immune Checkpoint PD-1-based Mechanisms of Tumor Immune Resistance and Strategies for Re-treatment After Drug ResistanceLI Yuxin0JIN Feng1Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, ChinaDepartment of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550004, ChinaImmunotherapy is considered as the fourth cancer treatment after surgery, radiotherapy and chemotherapy. With the in-depth research on immunotherapy in recent years, especially immuno-checkpoint inhibitors, PD-1/PD-L1 pathway inhibitors have been approved for the treatment of many cancer species. But due to the immune response of tumor cells through multiple drug-resistant mechanisms, immuno-checkpoint blockade has some problems, such as low overall response rate, primary or secondary drug resistance and so on. This paper expounds the mechanism of tumor immune resistance and explores strategies for further treatment after drug resistance, which provides a new theoretical and clinical basis for improving the response rate of immune checkpoint inhibitors and reducing the probability of immune resistance.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.1296immunotherapyimmune checkpoint blockadeimmune resistancere-treatment after immune resistance |
| spellingShingle | LI Yuxin JIN Feng Immune Checkpoint PD-1-based Mechanisms of Tumor Immune Resistance and Strategies for Re-treatment After Drug Resistance Zhongliu Fangzhi Yanjiu immunotherapy immune checkpoint blockade immune resistance re-treatment after immune resistance |
| title | Immune Checkpoint PD-1-based Mechanisms of Tumor Immune Resistance and Strategies for Re-treatment After Drug Resistance |
| title_full | Immune Checkpoint PD-1-based Mechanisms of Tumor Immune Resistance and Strategies for Re-treatment After Drug Resistance |
| title_fullStr | Immune Checkpoint PD-1-based Mechanisms of Tumor Immune Resistance and Strategies for Re-treatment After Drug Resistance |
| title_full_unstemmed | Immune Checkpoint PD-1-based Mechanisms of Tumor Immune Resistance and Strategies for Re-treatment After Drug Resistance |
| title_short | Immune Checkpoint PD-1-based Mechanisms of Tumor Immune Resistance and Strategies for Re-treatment After Drug Resistance |
| title_sort | immune checkpoint pd 1 based mechanisms of tumor immune resistance and strategies for re treatment after drug resistance |
| topic | immunotherapy immune checkpoint blockade immune resistance re-treatment after immune resistance |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2022.21.1296 |
| work_keys_str_mv | AT liyuxin immunecheckpointpd1basedmechanismsoftumorimmuneresistanceandstrategiesforretreatmentafterdrugresistance AT jinfeng immunecheckpointpd1basedmechanismsoftumorimmuneresistanceandstrategiesforretreatmentafterdrugresistance |