Rosinidin Flavonoid Ameliorates Hyperglycemia, Lipid Pathways and Proinflammatory Cytokines in Streptozotocin-Induced Diabetic Rats
Diabetes is one of the world’s most important public health issues, impacting both public health and socioeconomic advancement; moreover, current pharmacotherapy is still insufficient. The natural flavonoid rosinidin has a long history of use in pharmaceuticals and nutritional supplements, but its r...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/3/547 |
| _version_ | 1797443639187603456 |
|---|---|
| author | Sadaf Jamal Gilani May Nasser Bin-Jumah Fahad A. Al-Abbasi Muhammad Shahid Nadeem Syed Sarim Imam Sultan Alshehri Mohammed M. Ghoneim Muhammad Afzal Sami I. Alzarea Nadeem Sayyed Imran Kazmi |
| author_facet | Sadaf Jamal Gilani May Nasser Bin-Jumah Fahad A. Al-Abbasi Muhammad Shahid Nadeem Syed Sarim Imam Sultan Alshehri Mohammed M. Ghoneim Muhammad Afzal Sami I. Alzarea Nadeem Sayyed Imran Kazmi |
| author_sort | Sadaf Jamal Gilani |
| collection | DOAJ |
| description | Diabetes is one of the world’s most important public health issues, impacting both public health and socioeconomic advancement; moreover, current pharmacotherapy is still insufficient. The natural flavonoid rosinidin has a long history of use in pharmaceuticals and nutritional supplements, but its role in diabetes has been unknown. The current study was intended to confirm the anti-diabetic activity of rosinidin in our laboratory setting, along with its mechanism. Streptozotocin (60 mg/kg, ip) treatment used to induce type II diabetes in rats and the test medication rosinidin was then administered orally (at doses of 10 mg/kg and 20 mg/kg) for biochemical and histopathological analysis. Treatment with rosinidin reduced negative consequences of diabetes. Rosinidin exerted a protective effect on a number of characteristics, including anti-diabetic responses (lower blood glucose, higher serum insulin and improved pancreatic function) and molecular mechanisms (favorable effects on lipid profiles, total protein, albumin, liver glycogen, proinflammatory cytokine, antioxidant and oxidative stress markers, AST, ALT and urea). Furthermore, the improved pancreatic architecture observed in tissues substantiated the favourable actions of rosinidin in STZ-induced diabetic rats. |
| first_indexed | 2024-03-09T12:58:59Z |
| format | Article |
| id | doaj.art-95f398e1eb8d43f980b44cc6ff613a33 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T12:58:59Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-95f398e1eb8d43f980b44cc6ff613a332023-11-30T21:56:26ZengMDPI AGPharmaceutics1999-49232022-02-0114354710.3390/pharmaceutics14030547Rosinidin Flavonoid Ameliorates Hyperglycemia, Lipid Pathways and Proinflammatory Cytokines in Streptozotocin-Induced Diabetic RatsSadaf Jamal Gilani0May Nasser Bin-Jumah1Fahad A. Al-Abbasi2Muhammad Shahid Nadeem3Syed Sarim Imam4Sultan Alshehri5Mohammed M. Ghoneim6Muhammad Afzal7Sami I. Alzarea8Nadeem Sayyed9Imran Kazmi10Department of Basic Health Sciences, Preparatory Year, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi ArabiaBiology Department, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, King Abdulaziz University Jeddah, Jeddah 21589, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, King Abdulaziz University Jeddah, Jeddah 21589, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi ArabiaDepartment of Pharmacology, College of Pharmacy, Jouf University, Aljouf, Sakaka 72341, Saudi ArabiaDepartment of Pharmacology, College of Pharmacy, Jouf University, Aljouf, Sakaka 72341, Saudi ArabiaSchool of Pharmacy, Glocal University, Saharanpur 247121, IndiaDepartment of Biochemistry, Faculty of Science, King Abdulaziz University Jeddah, Jeddah 21589, Saudi ArabiaDiabetes is one of the world’s most important public health issues, impacting both public health and socioeconomic advancement; moreover, current pharmacotherapy is still insufficient. The natural flavonoid rosinidin has a long history of use in pharmaceuticals and nutritional supplements, but its role in diabetes has been unknown. The current study was intended to confirm the anti-diabetic activity of rosinidin in our laboratory setting, along with its mechanism. Streptozotocin (60 mg/kg, ip) treatment used to induce type II diabetes in rats and the test medication rosinidin was then administered orally (at doses of 10 mg/kg and 20 mg/kg) for biochemical and histopathological analysis. Treatment with rosinidin reduced negative consequences of diabetes. Rosinidin exerted a protective effect on a number of characteristics, including anti-diabetic responses (lower blood glucose, higher serum insulin and improved pancreatic function) and molecular mechanisms (favorable effects on lipid profiles, total protein, albumin, liver glycogen, proinflammatory cytokine, antioxidant and oxidative stress markers, AST, ALT and urea). Furthermore, the improved pancreatic architecture observed in tissues substantiated the favourable actions of rosinidin in STZ-induced diabetic rats.https://www.mdpi.com/1999-4923/14/3/547rosinidinstreptozotocindiabeteslipid profileproinflammatory cytokine |
| spellingShingle | Sadaf Jamal Gilani May Nasser Bin-Jumah Fahad A. Al-Abbasi Muhammad Shahid Nadeem Syed Sarim Imam Sultan Alshehri Mohammed M. Ghoneim Muhammad Afzal Sami I. Alzarea Nadeem Sayyed Imran Kazmi Rosinidin Flavonoid Ameliorates Hyperglycemia, Lipid Pathways and Proinflammatory Cytokines in Streptozotocin-Induced Diabetic Rats Pharmaceutics rosinidin streptozotocin diabetes lipid profile proinflammatory cytokine |
| title | Rosinidin Flavonoid Ameliorates Hyperglycemia, Lipid Pathways and Proinflammatory Cytokines in Streptozotocin-Induced Diabetic Rats |
| title_full | Rosinidin Flavonoid Ameliorates Hyperglycemia, Lipid Pathways and Proinflammatory Cytokines in Streptozotocin-Induced Diabetic Rats |
| title_fullStr | Rosinidin Flavonoid Ameliorates Hyperglycemia, Lipid Pathways and Proinflammatory Cytokines in Streptozotocin-Induced Diabetic Rats |
| title_full_unstemmed | Rosinidin Flavonoid Ameliorates Hyperglycemia, Lipid Pathways and Proinflammatory Cytokines in Streptozotocin-Induced Diabetic Rats |
| title_short | Rosinidin Flavonoid Ameliorates Hyperglycemia, Lipid Pathways and Proinflammatory Cytokines in Streptozotocin-Induced Diabetic Rats |
| title_sort | rosinidin flavonoid ameliorates hyperglycemia lipid pathways and proinflammatory cytokines in streptozotocin induced diabetic rats |
| topic | rosinidin streptozotocin diabetes lipid profile proinflammatory cytokine |
| url | https://www.mdpi.com/1999-4923/14/3/547 |
| work_keys_str_mv | AT sadafjamalgilani rosinidinflavonoidameliorateshyperglycemialipidpathwaysandproinflammatorycytokinesinstreptozotocininduceddiabeticrats AT maynasserbinjumah rosinidinflavonoidameliorateshyperglycemialipidpathwaysandproinflammatorycytokinesinstreptozotocininduceddiabeticrats AT fahadaalabbasi rosinidinflavonoidameliorateshyperglycemialipidpathwaysandproinflammatorycytokinesinstreptozotocininduceddiabeticrats AT muhammadshahidnadeem rosinidinflavonoidameliorateshyperglycemialipidpathwaysandproinflammatorycytokinesinstreptozotocininduceddiabeticrats AT syedsarimimam rosinidinflavonoidameliorateshyperglycemialipidpathwaysandproinflammatorycytokinesinstreptozotocininduceddiabeticrats AT sultanalshehri rosinidinflavonoidameliorateshyperglycemialipidpathwaysandproinflammatorycytokinesinstreptozotocininduceddiabeticrats AT mohammedmghoneim rosinidinflavonoidameliorateshyperglycemialipidpathwaysandproinflammatorycytokinesinstreptozotocininduceddiabeticrats AT muhammadafzal rosinidinflavonoidameliorateshyperglycemialipidpathwaysandproinflammatorycytokinesinstreptozotocininduceddiabeticrats AT samiialzarea rosinidinflavonoidameliorateshyperglycemialipidpathwaysandproinflammatorycytokinesinstreptozotocininduceddiabeticrats AT nadeemsayyed rosinidinflavonoidameliorateshyperglycemialipidpathwaysandproinflammatorycytokinesinstreptozotocininduceddiabeticrats AT imrankazmi rosinidinflavonoidameliorateshyperglycemialipidpathwaysandproinflammatorycytokinesinstreptozotocininduceddiabeticrats |