Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling

Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling

Pulmonary endothelial barrier dysfunction is a hallmark of clinical pulmonary edema and contributes to the development of acute lung injury (ALI). Here we reported that ruscogenin (RUS), an effective steroidal sapogenin of Radix Ophiopogon japonicus, attenuated lipopolysaccharides (LPS)-induced pulm...

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Bibliographic Details
Main Authors: Yunhao Wu, Xiu Yu, Yuwei Wang, Yalin Huang, Jiahui Tang, Shuaishuai Gong, Siyu Jiang, Yuanli Xia, Fang Li, Boyang Yu, Yuanyuan Zhang, Junping Kou
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ruscogenin
Acute lung injury
Lipopolysaccharide
Endothelial barrier
Non-muscle myosin heavy chain IIA
TLR4
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521003592

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