Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer
Abstract Lung cancer is the leading cause of cancer-related deaths worldwide. Fibroblast growth factor receptor 1 (FGFR1) gene amplification is one of the most prominent and potentially targetable genetic alterations in squamous-cell lung cancer (SQCLC). Highly selective tyrosine kinase inhibitors h...
| Main Authors: | , , , , , , , , , , , , |
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| פורמט: | Article |
| שפה: | English |
| יצא לאור: |
Nature Portfolio
2022-07-01
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| סדרה: | npj Precision Oncology |
| גישה מקוונת: | https://doi.org/10.1038/s41698-022-00296-2 |