Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer

Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer

Abstract Lung cancer is the leading cause of cancer-related deaths worldwide. Fibroblast growth factor receptor 1 (FGFR1) gene amplification is one of the most prominent and potentially targetable genetic alterations in squamous-cell lung cancer (SQCLC). Highly selective tyrosine kinase inhibitors h...

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Bibliographic Details
Main Authors: Omar Elakad, Björn Häupl, Vera Labitzky, Sha Yao, Stefan Küffer, Alexander von Hammerstein-Equord, Bernhard C. Danner, Manfred Jücker, Henning Urlaub, Tobias Lange, Philipp Ströbel, Thomas Oellerich, Hanibal Bohnenberger
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-022-00296-2

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