Prognostic Nutritional Index Predicts Response and Prognosis in Cancer Patients Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis
ObjectiveTo investigate the association between pretreatment prognostic nutritional index (PNI) and clinical survival outcomes for advanced-stage cancer patients treated with immune checkpoint inhibitors (ICIs).MethodsWe conducted a comprehensive literature search to identify eligible studies concer...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.823087/full |
| _version_ | 1818190707313082368 |
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| author | Liwei Ni Jing Huang Jiyuan Ding Junyan Kou Tingting Shao Jun Li Liujie Gao Wanzhen Zheng Zhen Wu |
| author_facet | Liwei Ni Jing Huang Jiyuan Ding Junyan Kou Tingting Shao Jun Li Liujie Gao Wanzhen Zheng Zhen Wu |
| author_sort | Liwei Ni |
| collection | DOAJ |
| description | ObjectiveTo investigate the association between pretreatment prognostic nutritional index (PNI) and clinical survival outcomes for advanced-stage cancer patients treated with immune checkpoint inhibitors (ICIs).MethodsWe conducted a comprehensive literature search to identify eligible studies concerning the relationship between pretreatment PNI and survival outcomes in advanced cancer patients treated with ICIs. Published data were extracted and pooled odds ratio (pOR) for objective response rate (ORR), disease control rate (DCR), and pooled hazard ratio (pHR) for overall survival (OS), progressive-free survival (PFS), along with 95% confidence intervals (95% CIs) were calculated.ResultsTwelve studies with 1,359 participants were included in our study. A higher level of PNI indicated a greater ORR (pOR = 2.17, 95% CI = 1.52–3.10) and favorable DCR (pOR = 2.48, 95% CI = 1.87–3.29). Low PNI was associated with a shorter OS (pHR = 2.24, 95% CI = 1.57–3.20) and unfavorable PFS (pHR = 1.61, 95% CI = 1.37–1.88).ConclusionLow PNI might be an effective biomarker of poor tumor response and adverse prognosis of advanced cancer patients with ICIs. Further studies are needed to verify the prognostic value of PNI in clinical practice. |
| first_indexed | 2024-12-12T00:02:59Z |
| format | Article |
| id | doaj.art-95f4bd922c574530bedc66823a447076 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-12T00:02:59Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-95f4bd922c574530bedc66823a4470762022-12-22T00:45:11ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-07-01910.3389/fnut.2022.823087823087Prognostic Nutritional Index Predicts Response and Prognosis in Cancer Patients Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-AnalysisLiwei NiJing HuangJiyuan DingJunyan KouTingting ShaoJun LiLiujie GaoWanzhen ZhengZhen WuObjectiveTo investigate the association between pretreatment prognostic nutritional index (PNI) and clinical survival outcomes for advanced-stage cancer patients treated with immune checkpoint inhibitors (ICIs).MethodsWe conducted a comprehensive literature search to identify eligible studies concerning the relationship between pretreatment PNI and survival outcomes in advanced cancer patients treated with ICIs. Published data were extracted and pooled odds ratio (pOR) for objective response rate (ORR), disease control rate (DCR), and pooled hazard ratio (pHR) for overall survival (OS), progressive-free survival (PFS), along with 95% confidence intervals (95% CIs) were calculated.ResultsTwelve studies with 1,359 participants were included in our study. A higher level of PNI indicated a greater ORR (pOR = 2.17, 95% CI = 1.52–3.10) and favorable DCR (pOR = 2.48, 95% CI = 1.87–3.29). Low PNI was associated with a shorter OS (pHR = 2.24, 95% CI = 1.57–3.20) and unfavorable PFS (pHR = 1.61, 95% CI = 1.37–1.88).ConclusionLow PNI might be an effective biomarker of poor tumor response and adverse prognosis of advanced cancer patients with ICIs. Further studies are needed to verify the prognostic value of PNI in clinical practice.https://www.frontiersin.org/articles/10.3389/fnut.2022.823087/fullprognostic nutritional indeximmune checkpoint inhibitormeta-analysiscancerprognosis carcinoma |
| spellingShingle | Liwei Ni Jing Huang Jiyuan Ding Junyan Kou Tingting Shao Jun Li Liujie Gao Wanzhen Zheng Zhen Wu Prognostic Nutritional Index Predicts Response and Prognosis in Cancer Patients Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis Frontiers in Nutrition prognostic nutritional index immune checkpoint inhibitor meta-analysis cancer prognosis carcinoma |
| title | Prognostic Nutritional Index Predicts Response and Prognosis in Cancer Patients Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis |
| title_full | Prognostic Nutritional Index Predicts Response and Prognosis in Cancer Patients Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis |
| title_fullStr | Prognostic Nutritional Index Predicts Response and Prognosis in Cancer Patients Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Prognostic Nutritional Index Predicts Response and Prognosis in Cancer Patients Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis |
| title_short | Prognostic Nutritional Index Predicts Response and Prognosis in Cancer Patients Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis |
| title_sort | prognostic nutritional index predicts response and prognosis in cancer patients treated with immune checkpoint inhibitors a systematic review and meta analysis |
| topic | prognostic nutritional index immune checkpoint inhibitor meta-analysis cancer prognosis carcinoma |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.823087/full |
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