Ligand-Induced Variations in Structural and Dynamical Properties Within an Enzyme Superfamily

Ligand-Induced Variations in Structural and Dynamical Properties Within an Enzyme Superfamily

Enzyme catalysis is a complex process involving several steps along the reaction coordinates, including substrate recognition and binding, chemical transformation, and product release. Evidence continues to emerge linking the functional and evolutionary role of conformational exchange processes in o...

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Bibliographic Details
Main Authors: Chitra Narayanan, David N. Bernard, Khushboo Bafna, Donald Gagné, Pratul K. Agarwal, Nicolas Doucet
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
enzyme catalysis
ligand binding
chemical shift projection analysis
CHESPA
pancreatic ribonucleases
nuclear magnetic resonance
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2018.00054/full

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