Statins in Depression: An Evidence-Based Overview of Mechanisms and Clinical Studies

Statins in Depression: An Evidence-Based Overview of Mechanisms and Clinical Studies

Background: Depression is a leading cause of disability, burdened by high levels of non-response to conventional antidepressants. Novel therapeutic strategies targeting non-monoaminergic pathways are sorely needed. The widely available and safe statins have several putative mechanisms of action, esp...

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Bibliographic Details
Main Authors: Riccardo De Giorgi, Nicola Rizzo Pesci, Alice Quinton, Franco De Crescenzo, Philip J. Cowen, Catherine J. Harmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Psychiatry
Subjects:
statin
HMG 3-hydroxy-3-methylglutaryl
depression
antidepressant
mechanism
review
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.702617/full

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