The Role of the Gut Microbial Metabolites in Autoimmune Diseases
The gut microbiota and their metabolites play a critical role in the maintenance of host immune homeostasis. The dysbiosis and gut microbiota-derived metabolites are closely associated with the initiation and development of multiple autoimmune diseases. Among the microbiota metabolites, short-chain...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2022-09-01
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| Series: | Xiehe Yixue Zazhi |
| Subjects: | |
| Online Access: | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0246 |
| _version_ | 1817980034781020160 |
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| author | JIANG Xu YANG Huaxia ZHANG Fengchun |
| author_facet | JIANG Xu YANG Huaxia ZHANG Fengchun |
| author_sort | JIANG Xu |
| collection | DOAJ |
| description | The gut microbiota and their metabolites play a critical role in the maintenance of host immune homeostasis. The dysbiosis and gut microbiota-derived metabolites are closely associated with the initiation and development of multiple autoimmune diseases. Among the microbiota metabolites, short-chain fatty acids, tryptophan and its derivatives, and bile acids are the most widely studied. In this review, the metabolic pathway of the microbiota metabolites, their functions in the immune response and the current findings on their correlation with autoimmune diseases are summarized, with the hope of revealing the role of gut microbiota-derived metabolites on the pathogenesis of autoimmune diseases. |
| first_indexed | 2024-04-13T22:49:25Z |
| format | Article |
| id | doaj.art-95f84e7e841d46548ae6bb092dc22ec6 |
| institution | Directory Open Access Journal |
| issn | 1674-9081 |
| language | zho |
| last_indexed | 2024-04-13T22:49:25Z |
| publishDate | 2022-09-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj.art-95f84e7e841d46548ae6bb092dc22ec62022-12-22T02:26:15ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812022-09-0113574775210.12290/xhyxzz.2022-0246The Role of the Gut Microbial Metabolites in Autoimmune DiseasesJIANG Xu0YANG Huaxia1ZHANG Fengchun2State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Education Key Laboratory, Beijing 100730, ChinaDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Education Key Laboratory, Beijing 100730, ChinaDepartment of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Education Key Laboratory, Beijing 100730, ChinaThe gut microbiota and their metabolites play a critical role in the maintenance of host immune homeostasis. The dysbiosis and gut microbiota-derived metabolites are closely associated with the initiation and development of multiple autoimmune diseases. Among the microbiota metabolites, short-chain fatty acids, tryptophan and its derivatives, and bile acids are the most widely studied. In this review, the metabolic pathway of the microbiota metabolites, their functions in the immune response and the current findings on their correlation with autoimmune diseases are summarized, with the hope of revealing the role of gut microbiota-derived metabolites on the pathogenesis of autoimmune diseases.https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0246gut microbial metabolitesautoimmune diseasesshort chain fatty acidstryptophanbile acids |
| spellingShingle | JIANG Xu YANG Huaxia ZHANG Fengchun The Role of the Gut Microbial Metabolites in Autoimmune Diseases Xiehe Yixue Zazhi gut microbial metabolites autoimmune diseases short chain fatty acids tryptophan bile acids |
| title | The Role of the Gut Microbial Metabolites in Autoimmune Diseases |
| title_full | The Role of the Gut Microbial Metabolites in Autoimmune Diseases |
| title_fullStr | The Role of the Gut Microbial Metabolites in Autoimmune Diseases |
| title_full_unstemmed | The Role of the Gut Microbial Metabolites in Autoimmune Diseases |
| title_short | The Role of the Gut Microbial Metabolites in Autoimmune Diseases |
| title_sort | role of the gut microbial metabolites in autoimmune diseases |
| topic | gut microbial metabolites autoimmune diseases short chain fatty acids tryptophan bile acids |
| url | https://xhyxzz.pumch.cn/en/article/doi/10.12290/xhyxzz.2022-0246 |
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