Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke
Ischemic stroke is one of the major contributors to death and disability worldwide. Thus, there is an urgent need to develop early brain tissue perfusion therapies following acute stroke and to enhance functional recovery in stroke survivors. The morbidity, therapy, and recovery processes are highly...
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| Format: | Article |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.980548/full |
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| author | Meiqi Jin Meiqi Jin Meiqi Jin Meiqi Jin Shuxia Zhang Shuxia Zhang Shuxia Zhang Shuxia Zhang Mengchen Wang Mengchen Wang Mengchen Wang Mengchen Wang Qiaoyu Li Qiaoyu Li Qiaoyu Li Qiaoyu Li Jiahui Ren Jiahui Ren Jiahui Ren Yun Luo Yun Luo Yun Luo Yun Luo Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun |
| author_facet | Meiqi Jin Meiqi Jin Meiqi Jin Meiqi Jin Shuxia Zhang Shuxia Zhang Shuxia Zhang Shuxia Zhang Mengchen Wang Mengchen Wang Mengchen Wang Mengchen Wang Qiaoyu Li Qiaoyu Li Qiaoyu Li Qiaoyu Li Jiahui Ren Jiahui Ren Jiahui Ren Yun Luo Yun Luo Yun Luo Yun Luo Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun |
| author_sort | Meiqi Jin |
| collection | DOAJ |
| description | Ischemic stroke is one of the major contributors to death and disability worldwide. Thus, there is an urgent need to develop early brain tissue perfusion therapies following acute stroke and to enhance functional recovery in stroke survivors. The morbidity, therapy, and recovery processes are highly orchestrated interactions involving the brain with other tissues. Exosomes are natural and ideal mediators of intercellular information transfer and recognized as biomarkers for disease diagnosis and prognosis. Changes in exosome contents express throughout the physiological process. Accumulating evidence demonstrates the use of exosomes in exploring unknown cellular and molecular mechanisms of intercellular communication and organ homeostasis and indicates their potential role in ischemic stroke. Inspired by the unique properties of exosomes, this review focuses on the communication, diagnosis, and therapeutic role of various derived exosomes, and their development and challenges for the treatment of cerebral ischemic stroke. |
| first_indexed | 2024-04-13T05:01:55Z |
| format | Article |
| id | doaj.art-95f8c1833c5241f0b07de806d15c3996 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-13T05:01:55Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-95f8c1833c5241f0b07de806d15c39962022-12-22T03:01:19ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-12-011010.3389/fbioe.2022.980548980548Exosomes in pathogenesis, diagnosis, and therapy of ischemic strokeMeiqi Jin0Meiqi Jin1Meiqi Jin2Meiqi Jin3Shuxia Zhang4Shuxia Zhang5Shuxia Zhang6Shuxia Zhang7Mengchen Wang8Mengchen Wang9Mengchen Wang10Mengchen Wang11Qiaoyu Li12Qiaoyu Li13Qiaoyu Li14Qiaoyu Li15Jiahui Ren16Jiahui Ren17Jiahui Ren18Yun Luo19Yun Luo20Yun Luo21Yun Luo22Xiaobo Sun23Xiaobo Sun24Xiaobo Sun25Xiaobo Sun26Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, ChinaNMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, ChinaInstitute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, ChinaNMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, ChinaInstitute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, ChinaNMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, ChinaInstitute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, ChinaNMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, ChinaInstitute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, ChinaInstitute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, ChinaNMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, ChinaInstitute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, ChinaNMPA Key Laboratory for Research and Evaluation of Pharmacovigilance, Beijing, ChinaIschemic stroke is one of the major contributors to death and disability worldwide. Thus, there is an urgent need to develop early brain tissue perfusion therapies following acute stroke and to enhance functional recovery in stroke survivors. The morbidity, therapy, and recovery processes are highly orchestrated interactions involving the brain with other tissues. Exosomes are natural and ideal mediators of intercellular information transfer and recognized as biomarkers for disease diagnosis and prognosis. Changes in exosome contents express throughout the physiological process. Accumulating evidence demonstrates the use of exosomes in exploring unknown cellular and molecular mechanisms of intercellular communication and organ homeostasis and indicates their potential role in ischemic stroke. Inspired by the unique properties of exosomes, this review focuses on the communication, diagnosis, and therapeutic role of various derived exosomes, and their development and challenges for the treatment of cerebral ischemic stroke.https://www.frontiersin.org/articles/10.3389/fbioe.2022.980548/fullexosomesischemic strokeblood vesselsneuroninflammationthe blood-brain barrier (BBB) |
| spellingShingle | Meiqi Jin Meiqi Jin Meiqi Jin Meiqi Jin Shuxia Zhang Shuxia Zhang Shuxia Zhang Shuxia Zhang Mengchen Wang Mengchen Wang Mengchen Wang Mengchen Wang Qiaoyu Li Qiaoyu Li Qiaoyu Li Qiaoyu Li Jiahui Ren Jiahui Ren Jiahui Ren Yun Luo Yun Luo Yun Luo Yun Luo Xiaobo Sun Xiaobo Sun Xiaobo Sun Xiaobo Sun Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke Frontiers in Bioengineering and Biotechnology exosomes ischemic stroke blood vessels neuron inflammation the blood-brain barrier (BBB) |
| title | Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke |
| title_full | Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke |
| title_fullStr | Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke |
| title_full_unstemmed | Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke |
| title_short | Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke |
| title_sort | exosomes in pathogenesis diagnosis and therapy of ischemic stroke |
| topic | exosomes ischemic stroke blood vessels neuron inflammation the blood-brain barrier (BBB) |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.980548/full |
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