Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies
Gastrulation constitutes a fundamental yet diverse morphogenetic process of metazoan development. Modes of gastrulation range from stochastic translocation of individual cells to coordinated infolding of an epithelial sheet. How such morphogenetic differences are genetically encoded and whether they...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-09-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/18318 |
| _version_ | 1811200456457715712 |
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| author | Silvia Urbansky Paula González Avalos Maike Wosch Steffen Lemke |
| author_facet | Silvia Urbansky Paula González Avalos Maike Wosch Steffen Lemke |
| author_sort | Silvia Urbansky |
| collection | DOAJ |
| description | Gastrulation constitutes a fundamental yet diverse morphogenetic process of metazoan development. Modes of gastrulation range from stochastic translocation of individual cells to coordinated infolding of an epithelial sheet. How such morphogenetic differences are genetically encoded and whether they have provided specific developmental advantages is unclear. Here we identify two genes, folded gastrulation and t48, which in the evolution of fly gastrulation acted as a likely switch from an ingression of individual cells to the invagination of the blastoderm epithelium. Both genes are expressed and required for mesoderm invagination in the fruit fly Drosophila melanogaster but do not appear during mesoderm ingression of the midge Chironomus riparius. We demonstrate that early expression of either or both of these genes in C.riparius is sufficient to invoke mesoderm invagination similar to D.melanogaster. The possible genetic simplicity and a measurable increase in developmental robustness might explain repeated evolution of similar transitions in animal gastrulation. |
| first_indexed | 2024-04-12T02:04:39Z |
| format | Article |
| id | doaj.art-95fa33e9dde34cb88fa3199486f073b5 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:04:39Z |
| publishDate | 2016-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-95fa33e9dde34cb88fa3199486f073b52022-12-22T03:52:35ZengeLife Sciences Publications LtdeLife2050-084X2016-09-01510.7554/eLife.18318Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in fliesSilvia Urbansky0Paula González Avalos1Maike Wosch2Steffen Lemke3https://orcid.org/0000-0001-5807-2865Centre for Organismal Studies Heidelberg, Heidelberg University, Heidelberg, GermanyCentre for Organismal Studies Heidelberg, Heidelberg University, Heidelberg, GermanyCentre for Organismal Studies Heidelberg, Heidelberg University, Heidelberg, GermanyCentre for Organismal Studies Heidelberg, Heidelberg University, Heidelberg, GermanyGastrulation constitutes a fundamental yet diverse morphogenetic process of metazoan development. Modes of gastrulation range from stochastic translocation of individual cells to coordinated infolding of an epithelial sheet. How such morphogenetic differences are genetically encoded and whether they have provided specific developmental advantages is unclear. Here we identify two genes, folded gastrulation and t48, which in the evolution of fly gastrulation acted as a likely switch from an ingression of individual cells to the invagination of the blastoderm epithelium. Both genes are expressed and required for mesoderm invagination in the fruit fly Drosophila melanogaster but do not appear during mesoderm ingression of the midge Chironomus riparius. We demonstrate that early expression of either or both of these genes in C.riparius is sufficient to invoke mesoderm invagination similar to D.melanogaster. The possible genetic simplicity and a measurable increase in developmental robustness might explain repeated evolution of similar transitions in animal gastrulation.https://elifesciences.org/articles/18318C. ripariusgastrulationmorphogenesiscell ingressiontissue invagination |
| spellingShingle | Silvia Urbansky Paula González Avalos Maike Wosch Steffen Lemke Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies eLife C. riparius gastrulation morphogenesis cell ingression tissue invagination |
| title | Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies |
| title_full | Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies |
| title_fullStr | Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies |
| title_full_unstemmed | Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies |
| title_short | Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies |
| title_sort | folded gastrulation and t48 drive the evolution of coordinated mesoderm internalization in flies |
| topic | C. riparius gastrulation morphogenesis cell ingression tissue invagination |
| url | https://elifesciences.org/articles/18318 |
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