Gene therapy with caspase-3 small interfering RNA-nanoparticles is neuroprotective after optic nerve damage

Gene therapy with caspase-3 small interfering RNA-nanoparticles is neuroprotective after optic nerve damage

Apoptosis, a key mechanism of programmed cell death, is triggered by caspase-3 protein and lowering its levels with gene therapy may rescue cell death after central nervous system damage. We developed a novel, non-viral gene therapy to block caspase-3 gene expression using small interfering RNA (siR...

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Bibliographic Details
Main Authors: Mohamed Tawfik, Xiwei Zhang, Lisa Grigartzik, Peter Heiduschka, Werner Hintz, Petra Henrich-Noack, Berend van Wachem, Bernhard A Sabel
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Neural Regeneration Research
Subjects:
apoptosis; brain; caspase-3; drug delivery; gene therapy; in vivo confocal neuroimaging; nanoparticles; neurodegeneration; neuroprotection; retina; sirna
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=12;spage=2534;epage=2541;aulast=Tawfik

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