Prognostic value of HER2/neu expression in patients with prostate cancer: a systematic review
Introduction: The prognostic value of Her2-positive expression has been investigated for malignancies such as breast cancer. We aimed to study the association between Her2 gene overexpression and clinical progression of hormone-independent prostate cancer. Methods: PubMed was searched to obtain the...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2015-09-01
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| Series: | Reviews in Clinical Medicine |
| Subjects: | |
| Online Access: | http://rcm.mums.ac.ir/pdf_4816_12c1f739054bf2057eebd8d49514387e.html |
| _version_ | 1818025827050192896 |
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| author | Mozhgan Moghadas niyat |
| author_facet | Mozhgan Moghadas niyat |
| author_sort | Mozhgan Moghadas niyat |
| collection | DOAJ |
| description | Introduction: The prognostic value of Her2-positive expression has been investigated for malignancies such as breast cancer. We aimed to study the association between Her2 gene overexpression and clinical progression of hormone-independent prostate cancer. Methods: PubMed was searched to obtain the relevant articles without language or date limit. Reference list of the relevant articles was also searched to prevent missing any relevant article. Data were extracted regarding the patients’ survival and disease-free survival. Results: Overall, 15 articles were obtained, which studied the prognostic value of Her2 overexpression in patients with prostate cancer. Based on obtained hazard ratio and calculated log-rank test, overexpression of Her2 was significantly associated with disease recurrence, overall survival and cause-specific survival. Discussion: Her2 expression can be considered as a mortality rate indicator in patients with metastatic prostate cancer and higher risk of disease recurrence (increase in PSA level) has been suggested in these patients with over expression of Her2.Conclusion: Despite various differences in included articles regarding methodology, results, sample size and individual differences, Her2 overexpression showed a positive relation with poor prognosis of prostate cancer regarding survival and disease recurrence. |
| first_indexed | 2024-12-10T04:22:17Z |
| format | Article |
| id | doaj.art-95fc07f1ee31411d9d1b2098dd9c6a76 |
| institution | Directory Open Access Journal |
| issn | 2345-6256 2345-6892 |
| language | English |
| last_indexed | 2024-12-10T04:22:17Z |
| publishDate | 2015-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj.art-95fc07f1ee31411d9d1b2098dd9c6a762022-12-22T02:02:22ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922015-09-01241681734816Prognostic value of HER2/neu expression in patients with prostate cancer: a systematic reviewMozhgan Moghadas niyat0Department of Pathology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Introduction: The prognostic value of Her2-positive expression has been investigated for malignancies such as breast cancer. We aimed to study the association between Her2 gene overexpression and clinical progression of hormone-independent prostate cancer. Methods: PubMed was searched to obtain the relevant articles without language or date limit. Reference list of the relevant articles was also searched to prevent missing any relevant article. Data were extracted regarding the patients’ survival and disease-free survival. Results: Overall, 15 articles were obtained, which studied the prognostic value of Her2 overexpression in patients with prostate cancer. Based on obtained hazard ratio and calculated log-rank test, overexpression of Her2 was significantly associated with disease recurrence, overall survival and cause-specific survival. Discussion: Her2 expression can be considered as a mortality rate indicator in patients with metastatic prostate cancer and higher risk of disease recurrence (increase in PSA level) has been suggested in these patients with over expression of Her2.Conclusion: Despite various differences in included articles regarding methodology, results, sample size and individual differences, Her2 overexpression showed a positive relation with poor prognosis of prostate cancer regarding survival and disease recurrence.http://rcm.mums.ac.ir/pdf_4816_12c1f739054bf2057eebd8d49514387e.htmlDisease free survivalOverall survivalProstate cancer |
| spellingShingle | Mozhgan Moghadas niyat Prognostic value of HER2/neu expression in patients with prostate cancer: a systematic review Reviews in Clinical Medicine Disease free survival Overall survival Prostate cancer |
| title | Prognostic value of HER2/neu expression in patients with prostate cancer: a systematic review |
| title_full | Prognostic value of HER2/neu expression in patients with prostate cancer: a systematic review |
| title_fullStr | Prognostic value of HER2/neu expression in patients with prostate cancer: a systematic review |
| title_full_unstemmed | Prognostic value of HER2/neu expression in patients with prostate cancer: a systematic review |
| title_short | Prognostic value of HER2/neu expression in patients with prostate cancer: a systematic review |
| title_sort | prognostic value of her2 neu expression in patients with prostate cancer a systematic review |
| topic | Disease free survival Overall survival Prostate cancer |
| url | http://rcm.mums.ac.ir/pdf_4816_12c1f739054bf2057eebd8d49514387e.html |
| work_keys_str_mv | AT mozhganmoghadasniyat prognosticvalueofher2neuexpressioninpatientswithprostatecancerasystematicreview |