Specific risk factors for cerebrovascular disorders in patients with chronic kidney disease in the pre-dialysis period
Cerebral vascular disorders are one of the leading causes of disability and mortality in patients with chronic kidney disease (CKD). The article presents the currently available data on risk factors (RF) for the development of cerebrovascular disorders in pre-dialysis patients with CKD. Two groups o...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2019-06-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/819 |
| _version_ | 1797882475584684032 |
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| author | A. E. Khrulev A. A. Nikitina N. S. Khruleva |
| author_facet | A. E. Khrulev A. A. Nikitina N. S. Khruleva |
| author_sort | A. E. Khrulev |
| collection | DOAJ |
| description | Cerebral vascular disorders are one of the leading causes of disability and mortality in patients with chronic kidney disease (CKD). The article presents the currently available data on risk factors (RF) for the development of cerebrovascular disorders in pre-dialysis patients with CKD. Two groups of RF are identified: traditional and non-traditional (specific). Traditional RF, which include arterial hypertension, diabetes mellitus and hypercholesterolemia, independently affect the cerebral vascular bed and get worse against the background of CKD. Specific RF is associated with features of the CKD pathogenesis. It includes increased blood levels of homocysteine, β2-microglobulin, impaired calcium-phosphorus metabolism, accumulation of uremic toxins and toxins of intestinal bacteria, anemia and other factors. In the present review, special attention is paid to specific RF and pathogenetic mechanisms of the development of cerebrovascular disorders in predialysis patients with CKD. Timely detection of cerebral risk factors may lead to the improvement of early diagnosis and prevention of cerebral vascular disorders, optimization of therapy for patients with CKD. |
| first_indexed | 2024-04-10T03:35:17Z |
| format | Article |
| id | doaj.art-95fd4425211b4b90825f0f6b6195e3a2 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:35:17Z |
| publishDate | 2019-06-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-95fd4425211b4b90825f0f6b6195e3a22023-03-13T07:23:27Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252019-06-01183889310.15829/1728-8800-2019-3-88-93615Specific risk factors for cerebrovascular disorders in patients with chronic kidney disease in the pre-dialysis periodA. E. Khrulev0A. A. Nikitina1N. S. Khruleva2ФГБОУ ВО «Приволжский исследовательский медицинский университет» Министерства здравоохранения Российской ФедерацииФГБОУ ВО «Приволжский исследовательский медицинский университет» Министерства здравоохранения Российской ФедерацииФГБОУ ВО «Приволжский исследовательский медицинский университет» Министерства здравоохранения Российской ФедерацииCerebral vascular disorders are one of the leading causes of disability and mortality in patients with chronic kidney disease (CKD). The article presents the currently available data on risk factors (RF) for the development of cerebrovascular disorders in pre-dialysis patients with CKD. Two groups of RF are identified: traditional and non-traditional (specific). Traditional RF, which include arterial hypertension, diabetes mellitus and hypercholesterolemia, independently affect the cerebral vascular bed and get worse against the background of CKD. Specific RF is associated with features of the CKD pathogenesis. It includes increased blood levels of homocysteine, β2-microglobulin, impaired calcium-phosphorus metabolism, accumulation of uremic toxins and toxins of intestinal bacteria, anemia and other factors. In the present review, special attention is paid to specific RF and pathogenetic mechanisms of the development of cerebrovascular disorders in predialysis patients with CKD. Timely detection of cerebral risk factors may lead to the improvement of early diagnosis and prevention of cerebral vascular disorders, optimization of therapy for patients with CKD.https://cardiovascular.elpub.ru/jour/article/view/819хроническая болезнь почекцереброваскулярные нарушенияинсультфакторы рискагипергомоцистеинемиявторичный амилоидозуремические токсинытоксины кишечных бактерийнарушение фосфорно-кальциевого обмена |
| spellingShingle | A. E. Khrulev A. A. Nikitina N. S. Khruleva Specific risk factors for cerebrovascular disorders in patients with chronic kidney disease in the pre-dialysis period Кардиоваскулярная терапия и профилактика хроническая болезнь почек цереброваскулярные нарушения инсульт факторы риска гипергомоцистеинемия вторичный амилоидоз уремические токсины токсины кишечных бактерий нарушение фосфорно-кальциевого обмена |
| title | Specific risk factors for cerebrovascular disorders in patients with chronic kidney disease in the pre-dialysis period |
| title_full | Specific risk factors for cerebrovascular disorders in patients with chronic kidney disease in the pre-dialysis period |
| title_fullStr | Specific risk factors for cerebrovascular disorders in patients with chronic kidney disease in the pre-dialysis period |
| title_full_unstemmed | Specific risk factors for cerebrovascular disorders in patients with chronic kidney disease in the pre-dialysis period |
| title_short | Specific risk factors for cerebrovascular disorders in patients with chronic kidney disease in the pre-dialysis period |
| title_sort | specific risk factors for cerebrovascular disorders in patients with chronic kidney disease in the pre dialysis period |
| topic | хроническая болезнь почек цереброваскулярные нарушения инсульт факторы риска гипергомоцистеинемия вторичный амилоидоз уремические токсины токсины кишечных бактерий нарушение фосфорно-кальциевого обмена |
| url | https://cardiovascular.elpub.ru/jour/article/view/819 |
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