Advances in Studies on Toxicity and Transformation of Zearalenone and Its Derivatives
Zearalenone (ZEN) is a mycotoxin produced by the Fusarium species, which has various toxic effects. The chemical structures of ZEN and its derivatives are similar to that of estrogen. When ingested by animals or humans, ZEN and its derivatives can lead to disturbance of estrogen balance, thereby har...
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| Format: | Article |
| Language: | English |
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China Food Publishing Company
2023-08-01
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| Series: | Shipin Kexue |
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| Online Access: | https://www.spkx.net.cn/fileup/1002-6630/PDF/2023-44-15-033.pdf |
| _version_ | 1827817938266095616 |
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| author | HE Yushuo, LI Mengmeng, LIU Yuanxiao, GUAN Erqi, JIN Rui, WANG Ruihu, BIAN Ke |
| author_facet | HE Yushuo, LI Mengmeng, LIU Yuanxiao, GUAN Erqi, JIN Rui, WANG Ruihu, BIAN Ke |
| author_sort | HE Yushuo, LI Mengmeng, LIU Yuanxiao, GUAN Erqi, JIN Rui, WANG Ruihu, BIAN Ke |
| collection | DOAJ |
| description | Zearalenone (ZEN) is a mycotoxin produced by the Fusarium species, which has various toxic effects. The chemical structures of ZEN and its derivatives are similar to that of estrogen. When ingested by animals or humans, ZEN and its derivatives can lead to disturbance of estrogen balance, thereby harming the reproductive system. Moreover, they can alter gene structure and consequently affect gene expression, and can even cause damage to the immune system, thus weakening the immune response. ZEN is transformed and metabolized into ZEN derivatives during food processing or after absorption by animals and plants, and its toxicity is altered due to structural and physicochemical changes. Studying the toxicity of ZEN and its derivatives as well as their transformation and metabolism in various organisms is important for ensuring food security and mycotoxin toxicity risk assessment. |
| first_indexed | 2024-03-12T00:41:24Z |
| format | Article |
| id | doaj.art-95fdf1f522a64855ad3364f84df40506 |
| institution | Directory Open Access Journal |
| issn | 1002-6630 |
| language | English |
| last_indexed | 2024-03-12T00:41:24Z |
| publishDate | 2023-08-01 |
| publisher | China Food Publishing Company |
| record_format | Article |
| series | Shipin Kexue |
| spelling | doaj.art-95fdf1f522a64855ad3364f84df405062023-09-15T07:43:31ZengChina Food Publishing CompanyShipin Kexue1002-66302023-08-01441528930910.7506/spkx1002-6630-20220823-278Advances in Studies on Toxicity and Transformation of Zearalenone and Its DerivativesHE Yushuo, LI Mengmeng, LIU Yuanxiao, GUAN Erqi, JIN Rui, WANG Ruihu, BIAN Ke0(College of Cereal and Food, Henan University of Technology, Zhengzhou 450001, China)Zearalenone (ZEN) is a mycotoxin produced by the Fusarium species, which has various toxic effects. The chemical structures of ZEN and its derivatives are similar to that of estrogen. When ingested by animals or humans, ZEN and its derivatives can lead to disturbance of estrogen balance, thereby harming the reproductive system. Moreover, they can alter gene structure and consequently affect gene expression, and can even cause damage to the immune system, thus weakening the immune response. ZEN is transformed and metabolized into ZEN derivatives during food processing or after absorption by animals and plants, and its toxicity is altered due to structural and physicochemical changes. Studying the toxicity of ZEN and its derivatives as well as their transformation and metabolism in various organisms is important for ensuring food security and mycotoxin toxicity risk assessment.https://www.spkx.net.cn/fileup/1002-6630/PDF/2023-44-15-033.pdfzearalenone; zearalenone derivatives; toxicity; transformation; mycotoxin |
| spellingShingle | HE Yushuo, LI Mengmeng, LIU Yuanxiao, GUAN Erqi, JIN Rui, WANG Ruihu, BIAN Ke Advances in Studies on Toxicity and Transformation of Zearalenone and Its Derivatives Shipin Kexue zearalenone; zearalenone derivatives; toxicity; transformation; mycotoxin |
| title | Advances in Studies on Toxicity and Transformation of Zearalenone and Its Derivatives |
| title_full | Advances in Studies on Toxicity and Transformation of Zearalenone and Its Derivatives |
| title_fullStr | Advances in Studies on Toxicity and Transformation of Zearalenone and Its Derivatives |
| title_full_unstemmed | Advances in Studies on Toxicity and Transformation of Zearalenone and Its Derivatives |
| title_short | Advances in Studies on Toxicity and Transformation of Zearalenone and Its Derivatives |
| title_sort | advances in studies on toxicity and transformation of zearalenone and its derivatives |
| topic | zearalenone; zearalenone derivatives; toxicity; transformation; mycotoxin |
| url | https://www.spkx.net.cn/fileup/1002-6630/PDF/2023-44-15-033.pdf |
| work_keys_str_mv | AT heyushuolimengmengliuyuanxiaoguanerqijinruiwangruihubianke advancesinstudiesontoxicityandtransformationofzearalenoneanditsderivatives |