Seroprevalence rates in children aged 3-6 years after implementing a two-dose varicella vaccination: A observational study
The study evaluates the outcomes of including varicella vaccines (VarV) in the local expanded programme on immunization (EPI) on the seropositivity rates and corresponding protective effects for children aged 3–6 years in Suzhou. The study is observational. Varicella prevalence in children was asses...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-01-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | http://dx.doi.org/10.1080/21645515.2023.2211465 |
| _version_ | 1827806347987517440 |
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| author | Zhuoyu Zhang Yunyan Zhang Jiangtao Yu Chen Dong Jun Zhang Na Liu Chihua Qian Lin Luan |
| author_facet | Zhuoyu Zhang Yunyan Zhang Jiangtao Yu Chen Dong Jun Zhang Na Liu Chihua Qian Lin Luan |
| author_sort | Zhuoyu Zhang |
| collection | DOAJ |
| description | The study evaluates the outcomes of including varicella vaccines (VarV) in the local expanded programme on immunization (EPI) on the seropositivity rates and corresponding protective effects for children aged 3–6 years in Suzhou. The study is observational. Varicella prevalence in children was assessed based on data from the China Information System for Disease Control and Prevention (CISDCP) and the Jiangsu Province Vaccination Integrated Service Management Information System (JPVISMIS). Seropositivity was determined using the enzyme-linked immunosorbent assay (ELISA). A total of 2,873 children aged 3–6 years were enrolled in this study. The seropositivity rates were 95.31% and 86.89% for children with and without the strategy, respectively. The difference in seropositivity rate in children using the different strategies was statistically significant (Trend χ2 = 0.397, P = .255). It is therefore suggested that Suzhou had a high rate of occult infection before the inclusion of varicella vaccine in the EPI. The difference in seroprevalence rate between children with no history of varicella vaccination and those with a history of varicella vaccination was statistically different (χ2 = 51.362, P < .001). The positive rates of antibodies increased with increasing doses of vaccination (χ2 = 56.252, P < .001). For the protective effect of one-dose and two-dose, it was found that the protection rates of one-dose were 72.98% and 100.00%, respectively. The varicella vaccine is an effective method to prevent varicella disease, which can increase serum seroprevalence levels and block the transmission of varicella disease. |
| first_indexed | 2024-03-11T21:39:55Z |
| format | Article |
| id | doaj.art-95fe037b323d4623879189356f206f7f |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T21:39:55Z |
| publishDate | 2023-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-95fe037b323d4623879189356f206f7f2023-09-26T13:25:50ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2023-01-0119110.1080/21645515.2023.22114652211465Seroprevalence rates in children aged 3-6 years after implementing a two-dose varicella vaccination: A observational studyZhuoyu Zhang0Yunyan Zhang1Jiangtao Yu2Chen Dong3Jun Zhang4Na Liu5Chihua Qian6Lin Luan7Nanjing Medical UniversitySuzhou Center for Disease Control and PreventionNanjing Medical UniversityMedical College of Soochow UniversitySuzhou Center for Disease Control and PreventionSuzhou Center for Disease Control and PreventionWuzhong District Center for Disease Control and PreventionNanjing Medical UniversityThe study evaluates the outcomes of including varicella vaccines (VarV) in the local expanded programme on immunization (EPI) on the seropositivity rates and corresponding protective effects for children aged 3–6 years in Suzhou. The study is observational. Varicella prevalence in children was assessed based on data from the China Information System for Disease Control and Prevention (CISDCP) and the Jiangsu Province Vaccination Integrated Service Management Information System (JPVISMIS). Seropositivity was determined using the enzyme-linked immunosorbent assay (ELISA). A total of 2,873 children aged 3–6 years were enrolled in this study. The seropositivity rates were 95.31% and 86.89% for children with and without the strategy, respectively. The difference in seropositivity rate in children using the different strategies was statistically significant (Trend χ2 = 0.397, P = .255). It is therefore suggested that Suzhou had a high rate of occult infection before the inclusion of varicella vaccine in the EPI. The difference in seroprevalence rate between children with no history of varicella vaccination and those with a history of varicella vaccination was statistically different (χ2 = 51.362, P < .001). The positive rates of antibodies increased with increasing doses of vaccination (χ2 = 56.252, P < .001). For the protective effect of one-dose and two-dose, it was found that the protection rates of one-dose were 72.98% and 100.00%, respectively. The varicella vaccine is an effective method to prevent varicella disease, which can increase serum seroprevalence levels and block the transmission of varicella disease.http://dx.doi.org/10.1080/21645515.2023.2211465varicella-zoster virusvaricella vaccineseroprevalencesuzhou |
| spellingShingle | Zhuoyu Zhang Yunyan Zhang Jiangtao Yu Chen Dong Jun Zhang Na Liu Chihua Qian Lin Luan Seroprevalence rates in children aged 3-6 years after implementing a two-dose varicella vaccination: A observational study Human Vaccines & Immunotherapeutics varicella-zoster virus varicella vaccine seroprevalence suzhou |
| title | Seroprevalence rates in children aged 3-6 years after implementing a two-dose varicella vaccination: A observational study |
| title_full | Seroprevalence rates in children aged 3-6 years after implementing a two-dose varicella vaccination: A observational study |
| title_fullStr | Seroprevalence rates in children aged 3-6 years after implementing a two-dose varicella vaccination: A observational study |
| title_full_unstemmed | Seroprevalence rates in children aged 3-6 years after implementing a two-dose varicella vaccination: A observational study |
| title_short | Seroprevalence rates in children aged 3-6 years after implementing a two-dose varicella vaccination: A observational study |
| title_sort | seroprevalence rates in children aged 3 6 years after implementing a two dose varicella vaccination a observational study |
| topic | varicella-zoster virus varicella vaccine seroprevalence suzhou |
| url | http://dx.doi.org/10.1080/21645515.2023.2211465 |
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