Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) – variety of symptoms
Introduction The autoimmune / inflammatory syndrome induced by adjuvants (ASIA) has been described by Shoenfeld and Agon-Levin (in 2011). It is an autoimmune / auto-inflammatory disease caused by adjuvants. Adjuvants are substances able to induce autoimmunity via various mechanisms such as a change...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2019-06-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/6971 |
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| author | Magdalena Makarewicz Katarzyna Łapa Magdalena Kubicka Barbara Maziarz Barbara Nieradko-Iwanicka |
| author_facet | Magdalena Makarewicz Katarzyna Łapa Magdalena Kubicka Barbara Maziarz Barbara Nieradko-Iwanicka |
| author_sort | Magdalena Makarewicz |
| collection | DOAJ |
| description | Introduction
The autoimmune / inflammatory syndrome induced by adjuvants (ASIA) has been described by Shoenfeld and Agon-Levin (in 2011). It is an autoimmune / auto-inflammatory disease caused by adjuvants. Adjuvants are substances able to induce autoimmunity via various mechanisms such as a change in the host immune system, polyclonal activation of B cells, effects on cellular immunity, immunoregulatory cells, antibodies induced by viruses or acceleration of molecular mimicry.
The aim
The purpose of the work was to congregate information about ASIA useful in medical practice.
State of knowledge
The ASIA syndrome can be diagnosed when two main or one main and two smaller criteria are fulfil.
The main criteria:
External stimulus exposure
Muscle pains, muscle inflammation or muscle weakness
Arthralgia and / or arthritis
Chronic fatigue, sleep without rest or sleep disorder
Neurological symptoms
Impaired cognitive function, memory loss
Fever, dry mouth
Removal of the inducing factor induces an improvement
Result of organ biopsy
Smaller criteria:
Other clinical signs (irritable bowel syndrome)
Presence of HLA antigens (ie HLA DRB1, HLA DQB1)
Development of autoimmune disease (multiple sclerosis, systemic sclerosis).
Asia syndrome may occur after implantation of silicone breast implants and cause various complications of other pain, fever and skin changes.
Conclusion
Autoimmune / auto-inflammatory disorders can be caused by silicone implants and vaccine adjuvants: they include the presence of autoantibodies, muscle and joint pain, lupus-like symptoms and hardened-like symptoms. |
| first_indexed | 2024-04-12T08:13:32Z |
| format | Article |
| id | doaj.art-95fea4119f3142abbc5601a64e78e750 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-04-12T08:13:32Z |
| publishDate | 2019-06-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-95fea4119f3142abbc5601a64e78e7502022-12-22T03:40:53ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062019-06-0196556310.5281/zenodo.32368056208Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) – variety of symptomsMagdalena Makarewicz0Katarzyna Łapa1Magdalena Kubicka2Barbara Maziarz3Barbara Nieradko-Iwanicka4Medical University of Lublin Chair and Department of Hygiene Al. Racławickie 1 20-059 Lublin NIP 7120106911Medical University in Lublin Chair and Department of Hygiene Al. Racławickie 1 20-059 Lublin NIP 7120106911Medical University in Lublin Chair and Department of Hygiene Al. Racławickie 1 20-059 Lublin NIP 7120106911Medical University in Lublin Chair and Department of Hygiene Al. Racławickie 1 20-059 Lublin NIP 7120106911Medical University in Lublin Chair and Department of Hygiene Al. Racławickie 1 20-059 Lublin NIP 7120106911Introduction The autoimmune / inflammatory syndrome induced by adjuvants (ASIA) has been described by Shoenfeld and Agon-Levin (in 2011). It is an autoimmune / auto-inflammatory disease caused by adjuvants. Adjuvants are substances able to induce autoimmunity via various mechanisms such as a change in the host immune system, polyclonal activation of B cells, effects on cellular immunity, immunoregulatory cells, antibodies induced by viruses or acceleration of molecular mimicry. The aim The purpose of the work was to congregate information about ASIA useful in medical practice. State of knowledge The ASIA syndrome can be diagnosed when two main or one main and two smaller criteria are fulfil. The main criteria: External stimulus exposure Muscle pains, muscle inflammation or muscle weakness Arthralgia and / or arthritis Chronic fatigue, sleep without rest or sleep disorder Neurological symptoms Impaired cognitive function, memory loss Fever, dry mouth Removal of the inducing factor induces an improvement Result of organ biopsy Smaller criteria: Other clinical signs (irritable bowel syndrome) Presence of HLA antigens (ie HLA DRB1, HLA DQB1) Development of autoimmune disease (multiple sclerosis, systemic sclerosis). Asia syndrome may occur after implantation of silicone breast implants and cause various complications of other pain, fever and skin changes. Conclusion Autoimmune / auto-inflammatory disorders can be caused by silicone implants and vaccine adjuvants: they include the presence of autoantibodies, muscle and joint pain, lupus-like symptoms and hardened-like symptoms.http://www.ojs.ukw.edu.pl/index.php/johs/article/view/6971asiaadjuvantsautoimmune syndrome |
| spellingShingle | Magdalena Makarewicz Katarzyna Łapa Magdalena Kubicka Barbara Maziarz Barbara Nieradko-Iwanicka Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) – variety of symptoms Journal of Education, Health and Sport asia adjuvants autoimmune syndrome |
| title | Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) – variety of symptoms |
| title_full | Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) – variety of symptoms |
| title_fullStr | Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) – variety of symptoms |
| title_full_unstemmed | Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) – variety of symptoms |
| title_short | Autoimmune / inflammatory syndrome induced by adjuvants (ASIA) – variety of symptoms |
| title_sort | autoimmune inflammatory syndrome induced by adjuvants asia variety of symptoms |
| topic | asia adjuvants autoimmune syndrome |
| url | http://www.ojs.ukw.edu.pl/index.php/johs/article/view/6971 |
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