Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative viral pathogen of coronavirus disease 2019 (COVID-19), appears to have various clinical presentations and may result in severe respiratory failure. The global SARS-CoV-2-associated viral pneumonia pandemic was first reported...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | Journal of Microbiology, Immunology and Infection |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S168411822030236X |
| _version_ | 1819169514779049984 |
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| author | Chih-Jen Yang Yu-Jui Wei Hsu-Liang Chang Pi-Yu Chang Chung-Chen Tsai Yen-Hsu Chen Po-Ren Hsueh |
| author_facet | Chih-Jen Yang Yu-Jui Wei Hsu-Liang Chang Pi-Yu Chang Chung-Chen Tsai Yen-Hsu Chen Po-Ren Hsueh |
| author_sort | Chih-Jen Yang |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative viral pathogen of coronavirus disease 2019 (COVID-19), appears to have various clinical presentations and may result in severe respiratory failure. The global SARS-CoV-2-associated viral pneumonia pandemic was first reported in December 2019 in China. Based on known pharmacological mechanisms, many therapeutic drugs have been repurposed to target SARS-CoV-2. Among these drugs, remdesivir appears to be the currently most promising according to several clinical trials and reports of compassionate use. In this mini-review, we summarize the current evidence on the efficacy and challenges of remdesivir for the treatment of coronavirus disease 2019 (COVID-19). |
| first_indexed | 2024-12-22T19:20:43Z |
| format | Article |
| id | doaj.art-95ffa30a8b8b4f6782a853293b272636 |
| institution | Directory Open Access Journal |
| issn | 1684-1182 |
| language | English |
| last_indexed | 2024-12-22T19:20:43Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Microbiology, Immunology and Infection |
| spelling | doaj.art-95ffa30a8b8b4f6782a853293b2726362022-12-21T18:15:23ZengElsevierJournal of Microbiology, Immunology and Infection1684-11822021-02-015412736Remdesivir use in the coronavirus disease 2019 pandemic: A mini-reviewChih-Jen Yang0Yu-Jui Wei1Hsu-Liang Chang2Pi-Yu Chang3Chung-Chen Tsai4Yen-Hsu Chen5Po-Ren Hsueh6Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Management, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Medical Information of Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan; Corresponding author. Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, No. 100, Tzyou First Road, Kaohsiung City, Taiwan. Fax: +886 7 316 1210.Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Corresponding author. Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung Shan South Road, Taipei, 100, Taiwan.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative viral pathogen of coronavirus disease 2019 (COVID-19), appears to have various clinical presentations and may result in severe respiratory failure. The global SARS-CoV-2-associated viral pneumonia pandemic was first reported in December 2019 in China. Based on known pharmacological mechanisms, many therapeutic drugs have been repurposed to target SARS-CoV-2. Among these drugs, remdesivir appears to be the currently most promising according to several clinical trials and reports of compassionate use. In this mini-review, we summarize the current evidence on the efficacy and challenges of remdesivir for the treatment of coronavirus disease 2019 (COVID-19).http://www.sciencedirect.com/science/article/pii/S168411822030236XSevere acute respiratory syndrome coronavirus 2Coronavirus disease 2019RemdesivirCompassionate use |
| spellingShingle | Chih-Jen Yang Yu-Jui Wei Hsu-Liang Chang Pi-Yu Chang Chung-Chen Tsai Yen-Hsu Chen Po-Ren Hsueh Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review Journal of Microbiology, Immunology and Infection Severe acute respiratory syndrome coronavirus 2 Coronavirus disease 2019 Remdesivir Compassionate use |
| title | Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review |
| title_full | Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review |
| title_fullStr | Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review |
| title_full_unstemmed | Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review |
| title_short | Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review |
| title_sort | remdesivir use in the coronavirus disease 2019 pandemic a mini review |
| topic | Severe acute respiratory syndrome coronavirus 2 Coronavirus disease 2019 Remdesivir Compassionate use |
| url | http://www.sciencedirect.com/science/article/pii/S168411822030236X |
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