Role of innate immunity in SARS-CoV-2 infection
During severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activated macrophages, dendritic cells (D.C.), neutrophils, and natural killer (N.K.) cells are the first defense against infection. These immune effectors trap and ingest the virus, kill infected epithelial cells, or pro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Biosafety and Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590053623001076 |
| _version_ | 1827783624679751680 |
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| author | Zihao Wang Fang Cheng Yuxiu Xu Xin Li Songdong Meng |
| author_facet | Zihao Wang Fang Cheng Yuxiu Xu Xin Li Songdong Meng |
| author_sort | Zihao Wang |
| collection | DOAJ |
| description | During severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activated macrophages, dendritic cells (D.C.), neutrophils, and natural killer (N.K.) cells are the first defense against infection. These immune effectors trap and ingest the virus, kill infected epithelial cells, or produce anti-viral cytokines. Evidence suggests that aging, obesity, and mental illness can lead to weakened innate immunity and, thus, are all associated with elevated infection and severe disease progression of coronavirus disease 2019 (COVID-19). Innate immune defense networks play a fundamental role in suppressing viral replication, infection establishment, and viral pathogenesis of SARS-CoV-2 and other respiratory viruses. |
| first_indexed | 2024-03-11T15:50:04Z |
| format | Article |
| id | doaj.art-960048f50ba74ffc8c123c61ce1f3e83 |
| institution | Directory Open Access Journal |
| issn | 2590-0536 |
| language | English |
| last_indexed | 2024-03-11T15:50:04Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biosafety and Health |
| spelling | doaj.art-960048f50ba74ffc8c123c61ce1f3e832023-10-26T04:18:20ZengElsevierBiosafety and Health2590-05362023-10-0155280288Role of innate immunity in SARS-CoV-2 infectionZihao Wang0Fang Cheng1Yuxiu Xu2Xin Li3Songdong Meng4Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaKey Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaKey Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaKey Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaKey Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Corresponding author: Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.During severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activated macrophages, dendritic cells (D.C.), neutrophils, and natural killer (N.K.) cells are the first defense against infection. These immune effectors trap and ingest the virus, kill infected epithelial cells, or produce anti-viral cytokines. Evidence suggests that aging, obesity, and mental illness can lead to weakened innate immunity and, thus, are all associated with elevated infection and severe disease progression of coronavirus disease 2019 (COVID-19). Innate immune defense networks play a fundamental role in suppressing viral replication, infection establishment, and viral pathogenesis of SARS-CoV-2 and other respiratory viruses.http://www.sciencedirect.com/science/article/pii/S2590053623001076Innate immunitySARS-CoV-2Traditional Chinese medicineDepressionHeat shock protein |
| spellingShingle | Zihao Wang Fang Cheng Yuxiu Xu Xin Li Songdong Meng Role of innate immunity in SARS-CoV-2 infection Biosafety and Health Innate immunity SARS-CoV-2 Traditional Chinese medicine Depression Heat shock protein |
| title | Role of innate immunity in SARS-CoV-2 infection |
| title_full | Role of innate immunity in SARS-CoV-2 infection |
| title_fullStr | Role of innate immunity in SARS-CoV-2 infection |
| title_full_unstemmed | Role of innate immunity in SARS-CoV-2 infection |
| title_short | Role of innate immunity in SARS-CoV-2 infection |
| title_sort | role of innate immunity in sars cov 2 infection |
| topic | Innate immunity SARS-CoV-2 Traditional Chinese medicine Depression Heat shock protein |
| url | http://www.sciencedirect.com/science/article/pii/S2590053623001076 |
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