Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has pleiotropic effects on neuronal morphology and synaptic plasticity that underlie hippocampal circuit development and cognition. Recent advances established that BDNF function is controlled and diversified by molecular and cellular m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2019.00135/full |
| _version_ | 1818842143839485952 |
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| author | Ana Paula De Vincenti Antonella S. Ríos Antonella S. Ríos Gustavo Paratcha Fernanda Ledda Fernanda Ledda |
| author_facet | Ana Paula De Vincenti Antonella S. Ríos Antonella S. Ríos Gustavo Paratcha Fernanda Ledda Fernanda Ledda |
| author_sort | Ana Paula De Vincenti |
| collection | DOAJ |
| description | Brain-derived neurotrophic factor (BDNF) is a neurotrophin that has pleiotropic effects on neuronal morphology and synaptic plasticity that underlie hippocampal circuit development and cognition. Recent advances established that BDNF function is controlled and diversified by molecular and cellular mechanisms including trafficking and subcellular compartmentalization of different Bdnf mRNA species, pre- vs. postsynaptic release of BDNF, control of BDNF signaling by tropomyosin receptor kinase B (TrkB) receptor interactors and conversion of pro-BDNF to mature BDNF and BDNF-propeptide. Defects in these regulatory mechanisms affect dendritic spine formation and morphology of pyramidal neurons as well as synaptic integration of newborn granule cells (GCs) into preexisting circuits of mature hippocampus, compromising the cognitive function. Here, we review recent findings describing novel dynamic mechanisms that diversify and locally control the function of BDNF in hippocampal neurons. |
| first_indexed | 2024-12-19T04:37:18Z |
| format | Article |
| id | doaj.art-96020f81514043f399ae32ece649039b |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-19T04:37:18Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-96020f81514043f399ae32ece649039b2022-12-21T20:35:44ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022019-04-011310.3389/fncel.2019.00135451592Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic PlasticityAna Paula De Vincenti0Antonella S. Ríos1Antonella S. Ríos2Gustavo Paratcha3Fernanda Ledda4Fernanda Ledda5División de Neurociencia Molecular y Celular, Instituto de Biología Celular y Neurociencias, Universidad de Buenos Aires, CONICET, Buenos Aires, ArgentinaDivisión de Neurociencia Molecular y Celular, Instituto de Biología Celular y Neurociencias, Universidad de Buenos Aires, CONICET, Buenos Aires, ArgentinaFundación Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires, CONICET, Buenos Aires, ArgentinaDivisión de Neurociencia Molecular y Celular, Instituto de Biología Celular y Neurociencias, Universidad de Buenos Aires, CONICET, Buenos Aires, ArgentinaDivisión de Neurociencia Molecular y Celular, Instituto de Biología Celular y Neurociencias, Universidad de Buenos Aires, CONICET, Buenos Aires, ArgentinaFundación Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires, CONICET, Buenos Aires, ArgentinaBrain-derived neurotrophic factor (BDNF) is a neurotrophin that has pleiotropic effects on neuronal morphology and synaptic plasticity that underlie hippocampal circuit development and cognition. Recent advances established that BDNF function is controlled and diversified by molecular and cellular mechanisms including trafficking and subcellular compartmentalization of different Bdnf mRNA species, pre- vs. postsynaptic release of BDNF, control of BDNF signaling by tropomyosin receptor kinase B (TrkB) receptor interactors and conversion of pro-BDNF to mature BDNF and BDNF-propeptide. Defects in these regulatory mechanisms affect dendritic spine formation and morphology of pyramidal neurons as well as synaptic integration of newborn granule cells (GCs) into preexisting circuits of mature hippocampus, compromising the cognitive function. Here, we review recent findings describing novel dynamic mechanisms that diversify and locally control the function of BDNF in hippocampal neurons.https://www.frontiersin.org/article/10.3389/fncel.2019.00135/fullBDNFPro-BDNFTrkBhippocampussynaptic plasticity |
| spellingShingle | Ana Paula De Vincenti Antonella S. Ríos Antonella S. Ríos Gustavo Paratcha Fernanda Ledda Fernanda Ledda Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity Frontiers in Cellular Neuroscience BDNF Pro-BDNF TrkB hippocampus synaptic plasticity |
| title | Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity |
| title_full | Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity |
| title_fullStr | Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity |
| title_full_unstemmed | Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity |
| title_short | Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity |
| title_sort | mechanisms that modulate and diversify bdnf functions implications for hippocampal synaptic plasticity |
| topic | BDNF Pro-BDNF TrkB hippocampus synaptic plasticity |
| url | https://www.frontiersin.org/article/10.3389/fncel.2019.00135/full |
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