The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker
Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox homeostasis, with proven involvement in a variety of pathophysiological conditions such as edema, glaucoma, nephrogenic diabetes insipidus, oxidative stress, sepsis, cancer, and metabolic dysfunctions. The 13 AQPs pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/7/897 |
| _version_ | 1797433831725203456 |
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| author | Inês V. da Silva Sabino Garra Giuseppe Calamita Graça Soveral |
| author_facet | Inês V. da Silva Sabino Garra Giuseppe Calamita Graça Soveral |
| author_sort | Inês V. da Silva |
| collection | DOAJ |
| description | Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox homeostasis, with proven involvement in a variety of pathophysiological conditions such as edema, glaucoma, nephrogenic diabetes insipidus, oxidative stress, sepsis, cancer, and metabolic dysfunctions. The 13 AQPs present in humans are widely distributed in all body districts, drawing cell lineage-specific expression patterns closely related to cell native functions. Compelling evidence indicates that AQPs are proteins with great potential as biomarkers and targets for therapeutic intervention. Aquaporin-9 (AQP9) is the most expressed in the liver, with implications in general metabolic and redox balance due to its aquaglyceroporin and peroxiporin activities, facilitating glycerol and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) diffusion across membranes. AQP9 is also expressed in other tissues, and their altered expression is described in several human diseases, such as liver injury, inflammation, cancer, infertility, and immune disorders. The present review compiles the current knowledge of AQP9 implication in diseases and highlights its potential as a new biomarker for diagnosis and prognosis in clinical medicine. |
| first_indexed | 2024-03-09T10:22:25Z |
| format | Article |
| id | doaj.art-9603106da9b34520802987577162c668 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T10:22:25Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-9603106da9b34520802987577162c6682023-12-01T21:55:20ZengMDPI AGBiomolecules2218-273X2022-06-0112789710.3390/biom12070897The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical BiomarkerInês V. da Silva0Sabino Garra1Giuseppe Calamita2Graça Soveral3Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, PortugalDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, ItalyDepartment of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, 70125 Bari, ItalyResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, PortugalAquaporins (AQPs) are transmembrane channels essential for water, energy, and redox homeostasis, with proven involvement in a variety of pathophysiological conditions such as edema, glaucoma, nephrogenic diabetes insipidus, oxidative stress, sepsis, cancer, and metabolic dysfunctions. The 13 AQPs present in humans are widely distributed in all body districts, drawing cell lineage-specific expression patterns closely related to cell native functions. Compelling evidence indicates that AQPs are proteins with great potential as biomarkers and targets for therapeutic intervention. Aquaporin-9 (AQP9) is the most expressed in the liver, with implications in general metabolic and redox balance due to its aquaglyceroporin and peroxiporin activities, facilitating glycerol and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) diffusion across membranes. AQP9 is also expressed in other tissues, and their altered expression is described in several human diseases, such as liver injury, inflammation, cancer, infertility, and immune disorders. The present review compiles the current knowledge of AQP9 implication in diseases and highlights its potential as a new biomarker for diagnosis and prognosis in clinical medicine.https://www.mdpi.com/2218-273X/12/7/897aquaporinsaquaporin-9clinical biomarkersmembrane permeability |
| spellingShingle | Inês V. da Silva Sabino Garra Giuseppe Calamita Graça Soveral The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker Biomolecules aquaporins aquaporin-9 clinical biomarkers membrane permeability |
| title | The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker |
| title_full | The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker |
| title_fullStr | The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker |
| title_full_unstemmed | The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker |
| title_short | The Multifaceted Role of Aquaporin-9 in Health and Its Potential as a Clinical Biomarker |
| title_sort | multifaceted role of aquaporin 9 in health and its potential as a clinical biomarker |
| topic | aquaporins aquaporin-9 clinical biomarkers membrane permeability |
| url | https://www.mdpi.com/2218-273X/12/7/897 |
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