Biomimetic nanoparticles blocking autophagy for enhanced chemotherapy and metastasis inhibition via reversing focal adhesion disassembly

Biomimetic nanoparticles blocking autophagy for enhanced chemotherapy and metastasis inhibition via reversing focal adhesion disassembly

Abstract Background Autophagy is a conserved catabolic process, which plays an important role in regulating tumor cell motility and degrading protein aggregates. Chemotherapy-induced autophagy may lead to tumor distant metastasis and even chemo-insensitivity in the therapy of hepatocellular carcinom...

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Bibliographic Details
Main Authors: Yesi Shi, Gan Lin, Huili Zheng, Dan Mu, Hu Chen, Zhixiang Lu, Pan He, Yang Zhang, Chao Liu, Zhongning Lin, Gang Liu
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Journal of Nanobiotechnology
Subjects:
Biomimetic
Targeted co-delivery
Autophagy inhibition
Focal adhesions
Metastasis
Online Access:https://doi.org/10.1186/s12951-021-01189-5

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