The Role of MicroRNA in the Pathogenesis of Diabetic Nephropathy
Diabetic nephropathy is one of the most common and severe complications of diabetes mellitus, affecting one in every five patients suffering from diabetes. Despite extensive research, the exact pathogenesis of diabetic nephropathy is still unclear. Several factors and pathways are known to be involv...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/7/6214 |
| _version_ | 1797607895387340800 |
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| author | Joanna Szostak Anna Gorący Damian Durys Paweł Dec Andrzej Modrzejewski Andrzej Pawlik |
| author_facet | Joanna Szostak Anna Gorący Damian Durys Paweł Dec Andrzej Modrzejewski Andrzej Pawlik |
| author_sort | Joanna Szostak |
| collection | DOAJ |
| description | Diabetic nephropathy is one of the most common and severe complications of diabetes mellitus, affecting one in every five patients suffering from diabetes. Despite extensive research, the exact pathogenesis of diabetic nephropathy is still unclear. Several factors and pathways are known to be involved in the development of the disease, such as reactive oxygen species or the activation of the renin–angiotensin–aldosterone system. The expression of those proteins might be extensively regulated by microRNA. Recent research suggests that in diabetic nephropathy patients, the profile of miRNA is significantly changed. In this review, we focus on the actions of miRNA in various pathways involved in the pathogenesis of diabetic nephropathy and the clinical usage of miRNAs as biomarkers and therapeutic targets. |
| first_indexed | 2024-03-11T05:35:59Z |
| format | Article |
| id | doaj.art-960513c667e346138acb2bbae8dd5eb0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:35:59Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-960513c667e346138acb2bbae8dd5eb02023-11-17T16:47:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01247621410.3390/ijms24076214The Role of MicroRNA in the Pathogenesis of Diabetic NephropathyJoanna Szostak0Anna Gorący1Damian Durys2Paweł Dec3Andrzej Modrzejewski4Andrzej Pawlik5Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandPlastic and Reconstructive Surgery Department, 109 Military Hospital, 71-422 Szczecin, PolandDepartment of Surgery, Pomeranian Medical University, 71-422 Szczecin, PolandDepartment of Physiology, Pomeranian Medical University, 70-111 Szczecin, PolandDiabetic nephropathy is one of the most common and severe complications of diabetes mellitus, affecting one in every five patients suffering from diabetes. Despite extensive research, the exact pathogenesis of diabetic nephropathy is still unclear. Several factors and pathways are known to be involved in the development of the disease, such as reactive oxygen species or the activation of the renin–angiotensin–aldosterone system. The expression of those proteins might be extensively regulated by microRNA. Recent research suggests that in diabetic nephropathy patients, the profile of miRNA is significantly changed. In this review, we focus on the actions of miRNA in various pathways involved in the pathogenesis of diabetic nephropathy and the clinical usage of miRNAs as biomarkers and therapeutic targets.https://www.mdpi.com/1422-0067/24/7/6214microRNAdiabetic nephropathydiabetes mellitusoxidative stresstransforming growth factor betabiomarkers |
| spellingShingle | Joanna Szostak Anna Gorący Damian Durys Paweł Dec Andrzej Modrzejewski Andrzej Pawlik The Role of MicroRNA in the Pathogenesis of Diabetic Nephropathy International Journal of Molecular Sciences microRNA diabetic nephropathy diabetes mellitus oxidative stress transforming growth factor beta biomarkers |
| title | The Role of MicroRNA in the Pathogenesis of Diabetic Nephropathy |
| title_full | The Role of MicroRNA in the Pathogenesis of Diabetic Nephropathy |
| title_fullStr | The Role of MicroRNA in the Pathogenesis of Diabetic Nephropathy |
| title_full_unstemmed | The Role of MicroRNA in the Pathogenesis of Diabetic Nephropathy |
| title_short | The Role of MicroRNA in the Pathogenesis of Diabetic Nephropathy |
| title_sort | role of microrna in the pathogenesis of diabetic nephropathy |
| topic | microRNA diabetic nephropathy diabetes mellitus oxidative stress transforming growth factor beta biomarkers |
| url | https://www.mdpi.com/1422-0067/24/7/6214 |
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