Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation Method
Nanoparticles are used in drug delivery which can increase mass transfer so increase the absorption and effectiveness of the drug. Therefore, its prospect to improve antibacterial and antioxidants activities of betel leaves. The research aimed to preparation and characterization of betel leaf extrac...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Mulawarman University
2020-06-01
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| Series: | Journal of Tropical Pharmacy and Chemistry |
| Subjects: | |
| Online Access: | https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/224 |
| _version_ | 1827771095247224832 |
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| author | Dwi Saryanti Dian Nugraheni Nisa Sindi Astuti |
| author_facet | Dwi Saryanti Dian Nugraheni Nisa Sindi Astuti |
| author_sort | Dwi Saryanti |
| collection | DOAJ |
| description | Nanoparticles are used in drug delivery which can increase mass transfer so increase the absorption and effectiveness of the drug. Therefore, its prospect to improve antibacterial and antioxidants activities of betel leaves. The research aimed to preparation and characterization of betel leaf extract using ionic gelation technique. The formulation of nanoparticles from betel leaf extract with ionic gelation method using alginate and CaCl2 with a ratio of 2.5: 1. The characterization of the nanoparticles includes particle size analysis, zeta potential, particle morphology and determination of flavonoid content. Particle size analysis demonstrated that the betel leaf extract nanoparticles had a particle size of 243,03 ± 1,48 nm, zeta potential of -23,0 ± 0,35 mV and morphology of particle showed that a flat shape. The betle leaf exctract nanoparticle positively contained flavonoid with Rf 0.7 equivalent to quercetin. The betel leaf extract can be made nanoparticles with ionic gelation method using alginate and CaCl2. |
| first_indexed | 2024-03-11T12:48:49Z |
| format | Article |
| id | doaj.art-96062a05a29f417a99108100ad6d821c |
| institution | Directory Open Access Journal |
| issn | 2087-7099 2407-6090 |
| language | English |
| last_indexed | 2024-03-11T12:48:49Z |
| publishDate | 2020-06-01 |
| publisher | Mulawarman University |
| record_format | Article |
| series | Journal of Tropical Pharmacy and Chemistry |
| spelling | doaj.art-96062a05a29f417a99108100ad6d821c2023-11-04T06:08:30ZengMulawarman UniversityJournal of Tropical Pharmacy and Chemistry2087-70992407-60902020-06-015110.25026/jtpc.v5i1.224Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation MethodDwi Saryanti0Dian Nugraheni1Nisa Sindi Astuti2Departemen Teknologi Farmasi Program Studi DIII Farmasi Stikes NasionalDepartemen Farmasi Komunitas, Program Studi DIII Farmasi Stikes NasionalDepartemen Mikrobiologi Program Studi DIII Farmasi Stikes NasionalNanoparticles are used in drug delivery which can increase mass transfer so increase the absorption and effectiveness of the drug. Therefore, its prospect to improve antibacterial and antioxidants activities of betel leaves. The research aimed to preparation and characterization of betel leaf extract using ionic gelation technique. The formulation of nanoparticles from betel leaf extract with ionic gelation method using alginate and CaCl2 with a ratio of 2.5: 1. The characterization of the nanoparticles includes particle size analysis, zeta potential, particle morphology and determination of flavonoid content. Particle size analysis demonstrated that the betel leaf extract nanoparticles had a particle size of 243,03 ± 1,48 nm, zeta potential of -23,0 ± 0,35 mV and morphology of particle showed that a flat shape. The betle leaf exctract nanoparticle positively contained flavonoid with Rf 0.7 equivalent to quercetin. The betel leaf extract can be made nanoparticles with ionic gelation method using alginate and CaCl2.https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/224NanoparticlesBetel Leaf ExtractIonic GelationPSASEM |
| spellingShingle | Dwi Saryanti Dian Nugraheni Nisa Sindi Astuti Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation Method Journal of Tropical Pharmacy and Chemistry Nanoparticles Betel Leaf Extract Ionic Gelation PSA SEM |
| title | Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation Method |
| title_full | Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation Method |
| title_fullStr | Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation Method |
| title_full_unstemmed | Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation Method |
| title_short | Preparation and Characterization of Betel Leaves (Piper betle Linn) Extract Nanoparticle with Ionic Gelation Method |
| title_sort | preparation and characterization of betel leaves piper betle linn extract nanoparticle with ionic gelation method |
| topic | Nanoparticles Betel Leaf Extract Ionic Gelation PSA SEM |
| url | https://jtpc.farmasi.unmul.ac.id/index.php/jtpc/article/view/224 |
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